期刊
CLINICAL INFECTIOUS DISEASES
卷 73, 期 5, 页码 903-906出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciab149
关键词
artesunate; dihydroartemisinin; severe malaria; pediatric dose selection; pharmacokinetic modeling and simulation
The World Health Organization recommends 3 mg/kg intravenous artesunate for pediatric patients weighing less than 20 kg for severe malaria treatment. The Food and Drug Administration, however, chose 2.4 mg/kg based on literature review and independent analyses for the same patient population.
For treatment of severe malaria, the World Health Organization recommends 3 mg/kg intravenous artesunate in pediatric patients weighing less than 20 kg. Here we describe the Food and Drug Administration's rationale for selecting 2.4 mg/kg in pediatric patients weighing less than 20 kg based on literature review and independent analyses.
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