期刊
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
卷 80, 期 2, 页码 139-151出版社
IOS PRESS
DOI: 10.3233/CH-201030
关键词
Rivaroxaban; coagulation inhibitors; venous thrombosis; clot structure; biomarkers
资金
- Engineering and Physical Sciences research council (EPSRC) Healthcare Impact Partnership [EP/LO24799/01]
- EPSRC Platform Award [EP/NO13506/01]
Rivaroxaban treatment has a protective effect against clot formation in DVT patients without significantly affecting clot microstructural properties.
BACKGROUND: The acute vascular disease deep vein thrombosis (DVT) requires oral anticoagulants to prevent progression. Monitoring therapeutic efficacy of direct oral anticoagulants (DOAC), including rivaroxaban, is problematic as no reliable test is available. Advances in rheometry have led to the development of a functional coagulation biomarker using Gel Point (GP) analysis which assesses clot structure formation. The biomarker measures incipient clot formation time (T-GP) and quantifies fibrin clot structure in terms of fractal dimension (d(f)). OBJECTIVE: This study aimed to investigate clot structure formation in first time DVT and the effect of rivaroxaban treatment. METHODS: This prospective observational cohort study measured the GP and standard laboratory markers at three sample points: pre-treatment and at 20 and 60 days following 15 mg BD and 20 mg OD rivaroxaban respectively. RESULTS: Forty DVT patients (mean age 64 years [SD +/- 14.8]; 23 males, 17 female) were recruited. The results show that DVT vs non-DVT patients did not have a significantly different GP profile (d(f): 1.72 +/- 0.06 vs 1.70 +/- 0.06 and T-GP: 267 +/- 68 sec vs 262 +/- 73 sec) with both within the defined healthy index. In addition, rivaroxaban therapy increased T-GP to 392 s (+/- 135 s) after 20 days, and subsequently increased to 395 s (+/- 194 s) at 60 days but did not significantly increase d(f) (from 1.69 +/- 0.05 to 1.71 +/- 0.06). CONCLUSIONS: The results indicate in this cohort of DVT patients there was no underlying hypercoagulable effect as determined by gel point analysis. Furthermore, the anticoagulant effect of rivaroxaban prolonged clotting, suggesting a protective effect against clot formation, without significantly reducing clot microstructural properties.
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