期刊
CLINICAL CANCER RESEARCH
卷 27, 期 10, 页码 2675-2677出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-21-0355
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资金
- NCI [T32 CA009515]
Targeting PSMA with AMG 160 shows promising preclinical efficacy in inducing T cell-driven cytolytic activity against prostate cancer, highlighting its potential therapeutic implications in immune oncology.
Targeting prostate-specific membrane antigen (PSMA) has important therapeutic ramifications, more recently including immune oncology. Data were recently presented on the preclinical efficacy of a half-life extended bispecific T-cell engager, AMG 160, which binds PSMA and CD3 to induce T-cell-driven cytolytic activity against prostate cancer.
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