期刊
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
卷 49, 期 3, 页码 270-288出版社
WILEY
DOI: 10.1111/ceo.13917
关键词
inherited retinal disease; retina; gene therapy; pharmacological therapy; stem cell
资金
- Foundation Fighting Blindness (USA)
- Retina UK
- Moorfields Eye Charity
- Moorfields Eye Hospital Special Trustees
- Wellcome Trust [099173/Z/12/Z]
- Leventis Foundation
- Onassis Foundation
- Fight for Sight (UK)
- Macular Society (UK)
- UCL Institute of Ophthalmology
- National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust
- Wellcome Trust [099173/Z/12/Z] Funding Source: Wellcome Trust
Inherited retinal diseases are a group of disorders characterized by photoreceptor degeneration or dysfunction, leading to severe vision loss. The advancements in genetics, retinal imaging, and molecular biology have paved the way for the development of treatments such as gene therapy and ongoing clinical trials targeting various retinal dystrophies. The current research aims to explore novel therapies for these diseases and improve patient outcomes.
Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders characterised by photoreceptor degeneration or dysfunction. These disorders typically present with severe vision loss that can be progressive, with disease onset ranging from congenital to late adulthood. The advances in genetics, retinal imaging and molecular biology, have conspired to create the ideal environment for establishing treatments for IRDs, with the first approved gene therapy and the commencement of multiple clinical trials. The scope of this review is to familiarise clinicians and scientists with the current management and the prospects for novel therapies for: (1) macular dystrophies, (2) cone and cone-rod dystrophies, (3) cone dysfunction syndromes, (4) Leber congenital amaurosis, (5) rod-cone dystrophies, (6) rod dysfunction syndromes and (7) chorioretinal dystrophies. We also briefly summarise the investigated end points for the ongoing trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据