期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 204, 期 2, 页码 179-188出版社
WILEY
DOI: 10.1111/cei.13589
关键词
immunopeptidomics; MHC peptides; peptide splicing
类别
资金
- Australian National Health and Medical Research Council (NHMRC) [1165490, 1084283]
- NHMRC [1137739]
- Victorian Government Department of Health and Human Services acting through the Victorian Cancer Agency
- National Health and Medical Research Council of Australia [1137739, 1165490, 1084283] Funding Source: NHMRC
Peptides bound to human leucocyte antigen (HLA) molecules on the cell surface are crucial for adaptive immunity, and a significant proportion of them are generated through splicing/fusion of discontinuous peptide segments from different proteins rather than simple proteolysis. Recent global analysis suggests a role for spliced peptides in the HLA class I immunopeptidome.
Peptides that bind to and are presented on the cell surface by human leucocyte antigen (HLA) molecules play a critical role in adaptive immunity. For a long time it was believed that all the HLA-bound peptides were generated through simple proteolysis of linear sequences of cellular proteins, and therefore are templated in the genome and proteome. However, evidence for untemplated peptide ligands of HLA molecules has accumulated during the last two decades, with a recent global analysis of HLA-bound peptides suggesting that a considerable proportion of HLA-bound peptides are potentially generated through splicing/fusion of discontinuous peptide segments from one or two distinct proteins. In this review, we will evaluate recent discoveries and debates on the contribution of spliced peptides to the HLA class I immunopeptidome, consider biochemical rules for splicing and the potential role of these spliced peptides in immune recognition.
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