期刊
CHINESE JOURNAL OF CHEMISTRY
卷 39, 期 7, 页码 1849-1854出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.202100043
关键词
Acetaminophen; Nickel phosphide; Electrochemistry; Sensors; Nanotechnology
资金
- National Natural Science Foundation of China [21705103]
- Applied Basic Research Project of Shanxi Province [201801D221392]
- Scientific and Technological Innovation Projects in Shanxi Universities [2019L0460]
- Graduate Education Innovation Project of Shanxi Normal University [2019XBY019]
- Science Research and Development Foundation of Kangda College of Nanjing Medical University [KD2020KYJJYB075]
- 1331 Engineering of Shanxi Province
This study successfully constructed an electrochemical acetaminophen sensor based on Ni2P nanosheets, which exhibited a good linear range, moderate sensitivity, and low detection limit, as well as excellent selectivity, stability, and repeatability. The sensor can be used for quantitative detection of acetaminophen in commercial medical drugs.
Main observation and conclusion Accurate determination of acetaminophen concentration is essential for studying the metabolic status of acetaminophen in clinical practice. In this study, nickel phosphide was used for electrochemical detection of acetaminophen for the first time. An electrochemical acetaminophen sensor based on Ni2P nanosheets was successfully constructed and the sensor showed many convincing properties: (a) a good linear range (0.5 mu mol/L-4.5 mmol/L); (b) a moderate sensitivity (131.1 mu A center dot mmol(-1)center dot L center dot cm(-2)); (c) a low detection limit (0.107 mu mol/L). In addition, the sensor also showed excellent selectivity, robust stability and reliable repeatability. Further experiments demonstrate that the prepared sensor can be used for quantitative detection of acetaminophen in commercial medical drugs.
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