4.7 Article

Phthalide-derived oxaspiroangelioic acids A-C with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head

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Summary: A pair of neolignan enantiomers, (+)-/(-)-angelignanine, were isolated from the aqueous extract of Angelica sinensis root heads. Their structures were determined by spectroscopic data analysis and their absolute configurations were assigned using the circular dichroism method. Both enantiomers showed significant hypnotic effects in vivo at a dose of 10 mg/kg.

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