期刊
CHINESE CHEMICAL LETTERS
卷 32, 期 9, 页码 2865-2868出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2021.02.013
关键词
Ag@POF composite; Aptamer; Electrochemical aptasensor; Theophylline; Sensitive detection
资金
- National Natural Science Foundation of China [21801187]
A novel POF was prepared via Friedel-Crafts reaction, in which silver nanoparticles were embedded to generate an Ag@POF composite for fabricating an intriguing electrochemical aptasensor. The biosensor showed excellent electrochemical detection behavior, with ultra-sensitiveness, high selectivity, remarkable stability, good repeatability, and simple operability, even in various real samples, with a limit of detection of 0.191 pg/mL in a wide concentration range.
Porous organic frameworks (POFs) are excellently stable porous materials, which can be employed as host platforms to support metal nanoparticles as functional composites for various applications. Herein, a novel POF is successfully prepared via Friedel-Crafts reaction. Silver nanoparticles (Ag NPs) are embedded in the prepared POF to generate an Ag@POF composite, which not only possesses high surface area, outstanding physicochemical stability and outstretched pi-conjugation skeleton, but also exhibits preferable electrochemical stability and conductivity. This composite is able to immobilize a mass of aptamer strands to fabricate an intriguing electrochemical aptasensor. Electrochemical impedance spectroscopy (EIS) is a commonly used technology to analyze the electrochemical signal variation. The Ag@POF-based biosensor shows the excellent electrochemical detection behavior through analyzing EIS. For instance theophylline as a research mode, the Ag@POF based electrochemical aptasensor reveals ultra-sensitiveness, high selectivity, remarkable stability, good repeatability and simple operability even in various real samples. Notably, this aptasensor has the sensitive detection performance with the limit of detection of 0.191 pg/mL (1.06 pmol/L) in a wide concentration range of 5.0 x 10(-4) - 5.0 ng/mL (2.78 x 10(-3 )- 27.8 nmol/L). (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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