期刊
CHEMOSPHERE
卷 267, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2020.129200
关键词
NDMA-FP; RNTD; Transformation products; Chlorine; Sunlight
资金
- Long-range Research Initiative of the Japan Chemical Industry Association (JCIA) [PT04-01]
- Environment Research and Technology Development Fund of the Environmental Restoration and Conservation Agency of Japan [5-1653]
- JSPS KAKENHI [17H00786]
- Grants-in-Aid for Scientific Research [17H00786] Funding Source: KAKEN
NDMA, a probable carcinogenic disinfection by-product, can be formed following chloramination of ranitidine, and the study found a complex relationship between ranitidine transformation products and NDMA formation potential (NDMA-FP). Some transformation products were identified to influence the generation of NDMA-FP.
N-nitrosodimethylamine (NDMA), a probable carcinogenic disinfection by-product, can be formed with high molar yields following chloramination of ranitidine (RNTD), a histamine H 2 -receptor antagonist. Although RNTD and some of its transformation products (TPs) have been studied under chlorination and photo-irradiation, the relationship between RNTD TPs and NDMA formation potential (NDMA-FP) remaining after those processes is still unclear. This study investigated the effects of chlorination and/or photo-irradiation on NDMA-FP derived from RNTD, simulating an urban water environment receiving treated wastewater. After chlorination and/or photo-irradiation of RNTD, ten TPs including five new ones were identified by liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTof-MS). In addition, important RNTD TPs responsible for NDMA-FP (e.g., chlorinated and hydroxylated RNTD: TP-364) were also confirmed by the relationship between detected peak area and NDMA-FP. The results showed that NDMA-FP remained due to the presence of RNTD TPs, although RNTD itself was significantly removed by chlorination and/or photo-irradiation. TP-364 was only formed by chlorination of RNTD and could not be removed by photo-irradiation. TP-314 (a stereoisomer of RNTD), -299, and -286, which were mainly formed by photo-irradiation of RNTD but not by photo-irradiation after chlorination, had strong positive correlations with NDMA-FP (R-2 > 0.90; F-test, P < 0.01). (C) 2020 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据