期刊
CHEMOSPHERE
卷 264, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2020.128402
关键词
Biomonitoring; Pregnancy; Total mercury; Temporal trends; Hair; Hair-to-blood ratios
资金
- Health Canada's Chemicals Management Plan (CMP)
- Canadian Institutes of Health Research [MOP - 81285]
- Ontario Ministry of Environment
Prenatal exposure to total mercury (T-Hg) from both natural and anthropogenic sources can have potential impacts on future neurological and physiological functions. Hair is a useful indicator of chronic T-Hg exposure, and studies have shown a decrease in T-Hg levels in both hair and maternal blood during pregnancy. Low T-Hg levels were found in meconium, and mercury levels in blood and hair were correlated with consumption of large predatory fish.
Prenatal exposure to total mercury (T-Hg) comes from both natural and anthropogenic sources. T-Hg can cross the blood-brain and placental barriers, and may be associated with future neurological and physiological dysfunctions. Scalp hair is an optimal and non-invasive indicator of chronic T-Hg exposure. As part of the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, hair samples from 350 women were collected within weeks after giving birth, to determine temporal variations in T-Hg levels from preconception to delivery, and to compare these levels to corresponding levels measured in other matrices (maternal and umbilical cord blood, and infant's meconium). A maximum of 12 one-cm hair segments were cut starting at the scalp; segments closer to the scalp reflected recent exposure (within the last month). For proper comparison, the hair segments were matched with the collection dates for other matrices. GM hair T-Hg levels greatly decreased during pregnancy, from 0.26 mu g g(-1) (preconception or full-length hair) to 0.18 mu g g(-1) (at delivery or segments closer to the scalp). A similar decreasing trend was found for T-Hg in maternal blood: 1st trimester (0.60 mu g L-1) to 3rd trimester (0.47 mu g L-1). The median hair-to-blood ratios of T-Hg levels varied from 364 (1st trimester), to 408 (3rd trimester), to 229 (cord blood). Very low T-Hg levels were detected in meconium. Mercury levels in blood and hair correlated with consumption of large predatory fish. Crown Copyright (C) 2020 Published by Elsevier Ltd.
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