期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 336, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2021.109369
关键词
Phenolic compounds; Tropical fruit; Liver steatosis; Obesity; Antioxidant capacity; Adipose tissue
资金
- FAPERJ [E-26/202.829/2015, E-26/010.002632/2014]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [472711/2013-0]
- Embrapa SEG [03.14.13.002.00]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES) [001]
Regular consumption of a phenolic-rich smoothie can improve liver antioxidant status, prevent metabolic disorders, and ameliorate non-alcoholic fatty liver disease caused by high-fat diet consumption.
Consumption of foods rich in phenolic compounds can be beneficial for health. This study aimed to examine whether the consumption of a phenolic-rich smoothie, based on jucara, strawberry and banana, ameliorates metabolic status and liver damage of diet-induced obese mice. Forty male C57BL/6J mice were assigned into four groups (n = 10) and fed control diet with free access to water (C) or phenolic-rich smoothie (C-S), or fed high-fat diet with free access to water (HF) or phenolic-rich smoothie (HF-S) for five weeks. HF and HF-S groups had higher body weight gains than the C group, however the HF had a greater adipose index, higher plasma levels of glucose, insulin and leptin, as well as higher plasma and hepatic steatosis than C, C-S and HF-S groups. The liver oxidative stress markers were reduced in C-S and HF-S groups and the activity of catalase and glutathione peroxidase were higher compared with their counterparts. The present study suggests that regular consumption of a phenolic-rich smoothie improves the liver antioxidant status, prevents metabolic disorders and ameliorates non-alcoholic fatty liver disease caused by high-fat diet consumption.
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