期刊
CHEMICAL RECORD
卷 21, 期 10, 页码 2782-2807出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.202000185
关键词
heterocycles; biological activity; cycloaddition; diazocompounds; synthetic methods
资金
- CNPq [301873/2019-4, 305454/2017-0]
- CAPES
- FAPERJ [E-26/010.101106/2018, E-26/202.800/2017, E-26/203.191/2017]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
The triazole heterocycle is a privileged scaffold in medicinal chemistry, and various methods for its preparation are described. This paper discusses the development of new methods for the synthesis of 1,2,3-triazoles and the preparation of new triazole-functionalized biologically active molecules using classical approaches, highlighting the significant contributions from the research group in this field.
The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is present in a large number of biologically active molecules, including several drugs currently in the market. Due to their vast applications, a wide variety of methods are described for their preparation, such as the 1,3-dipolar cycloaddition and processes involving diazo compounds and diazo transfer reactions. Considering the significant number of contributions from our research group to this chemistry in recent decades, in this account we discuss both the development of new methods for the synthesis of 1,2,3-triazoles and the preparation of new triazole-functionalized biologically active molecules using classical approaches.
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