How and Why to Investigate Multicomponent Reactions Mechanisms? A Critical Review

We review the most innovative efforts and greatest challenges faced when elucidating multicomponent reactions (MCRs) mechanisms. When compared to traditional reactions, the often two or more concurrent reactions pathways and the greater number of possible intermediates in MCRs turn their mechanistic investigation both a harder and trickier task. The common approaches used to investigate reaction mechanisms are often unable to clarify MCRs mechanisms; hence few but clever approaches are currently used to determine these mechanisms and to depict their key transformations. Their complexity has required most innovative approaches and the use of a number of unique techniques that have shed light over the favored pathway selected from the myriad of alternatives theoretically available for MCRs. This review focuses on the most successful efforts applied by a few leading groups to perform these puzzlingly investigations.

Automated summary

Elucidating multicomponent reactions (MCRs) mechanisms presents significant challenges and requires innovative approaches and unique techniques. Common methods are often inadequate for clarifying MCRs mechanisms, thus only a few clever methods are currently used to determine these mysterious mechanisms.