期刊
CHEMICAL ENGINEERING SCIENCE
卷 230, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ces.2020.116171
关键词
Reinforcement learning; Optimization; BioSMB; Ion exchange chromatography; mAb
资金
- Department of Biotechnology, Ministry of Science and Technology [BT/COE/34/SP15097/2015]
This study introduces a novel approach based on reinforcement learning to separate charge variants in biopharmaceutical industry by optimizing flow rate, achieving good results in experimental validation. Compared to traditional trial and error methods, this approach shows higher efficiency in both optimization and computational aspects.
Process intensification in the form of continuous processing is presently being adopted by the biopharmaceutical industry as it offers significant advantages over conventional processing. Chromatographic steps form the core separation steps of a typical biopharma process due to their high selectivity and robustness. To this end, this paper proposes a novel approach based on reinforcement learning (RL), wherein a maximization problem is formulated for cation exchange chromatography for separation of charge variants by optimization of the process flowrate. Chromatography analysis and design toolkit have been used for process simulation and the optimum flow rate at which the yield is maximum and purity constraints are satisfied has been estimated based on the reward policy of RL. Results were experimentally validated and indicate that the proposed RL based approach is superior to the conventional trial and error method of optimizing flowrate in terms of both optimality and computational aspects (3X faster). (C) 2020 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据