期刊
CHEMICAL ENGINEERING JOURNAL
卷 417, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.129329
关键词
Adhesive hydrogel; Antibacterial; Catechol; Cellulose; Haemostasis; Wound healing
资金
- National Key R&D Program of China [2018YFD06003023]
- National Natural Science Foundation of China [21774021, 31971612]
- Award Program for Minjiang Scholar Professorship [KXNAD002A]
- Technology Cooperation and Exchange Project of Fujian Agriculture and Forestry University [KXb16002A]
- Natural Science Foundation of Fujian Province [2020J01555]
- Scientific Research Foundation of Graduate School of Fujian Agriculture and Forestry University [324-1122yb048]
The newly designed double-network adhesive hydrogels provide an effective solution for uncontrollable bleeding and wound infection, with rapid hemostatic ability, biocompatibility, and antibacterial properties, suitable for wound healing.
Uncontrollable bleeding and wound infection remain as the primary challenges for emergency surgical procedures, including deep and non-compressible bleeding in the clinic or on the battleground. To better control haemorrhaging immediately from irregularly shaped and non-compressible wounds, double-network adhesive hydrogels based on cellulose and 3,4-dihydroxyphenylalanine (DOPA)-cation copolymer were designed for wound healing. Due to the abundance of hydrogen bonding, pi-pi stacking, cation-pi and electrostatic interactions in the double-network adhesives, the hydrogel with good biocompatibility presented tissue-like mechanical strength with Young's modulus below 20 kPa. The catechol-cation cooperation effect enhances the wet adhesion of hydrogels to skin tissue surfaces. The blue-light-induced fast gelation networks provide rapid haemostasis ability of the hydrogels by sealing blood vessels. The quaternary ammonium cationic polymers have remarkable antibacterial properties and promote blood coagulation by erythrocyte and platelet aggregation. Furthermore, the hydrogel with 2.5% P(DOPMAm-co-MPTC) (AC/PDM2.5) exhibited better tissue adhesion strength than commercially available glue, better haemostatic capability than the gauze based on the mouse-tail amputation model, and higher performance compared to Tegaderm T in the rat full-thickness skin defect model. These adhesive hydrogels with fast gelling, rapid haemostasis, biocompatibility and antibacterial activity offer great promising applications in wound healing.
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