期刊
CELLULAR IMMUNOLOGY
卷 364, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2021.104341
关键词
Asthma; Lipid metabolism; T cell; Macrophage; Granulocyte
资金
- Major Project from the National Natural Science Foundation of China [81930003]
Asthma is a chronic inflammatory disease of the lungs with significant health and socioeconomic burden. Lipid metabolism, particularly in various cells, plays a crucial role in regulating cellular responses in the pathogenesis of asthma. Current pharmacological agents mainly target lipid metabolism for intervention.
Asthma is a chronic inflammatory disease of the lungs that poses a considerable health and socioeconomic burden. Several risk factors work synergistically to affect the progression of asthma. Lipid metabolism, especially in distinct cells such as T cells, macrophages, granulocytes, and non-immune cells, plays an essential role in the pathogenesis of asthma, as lipids are potent signaling molecules that regulate a multitude of cellular response. In this review, we focused on the metabolic pathways of lipid molecules, especially fatty acids and their derivatives, and summarized their roles in various cells during the pathogenesis of asthma along with the current pharmacological agents targeting lipid metabolism.
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