Coinfection with influenza A virus enhances SARS-CoV-2 infectivity

The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, in vivo, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV. Moreover, such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses, likely due to a unique feature of IAV to elevate ACE2 expression. This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection, and thus, prevention of IAV infection is of great significance during the COVID-19 pandemic.

Automated summary

The upcoming flu season in the Northern Hemisphere coinciding with the COVID-19 pandemic poses a potential threat to public health. Research shows that influenza A virus infection significantly enhances the infectivity of SARS-CoV-2, leading to increased viral load and more severe lung damage in coinfected individuals. Preventing influenza A infection is crucial in controlling the spread of COVID-19.