期刊
CELL CYCLE
卷 20, 期 5-6, 页码 603-615出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2021.1892321
关键词
Retinoblastoma (RB); p53; miR-129; MDM2; 4; feedback loop
类别
This study found a positive correlation between p53 and miR-129 in RB, where miR-129 directly targeted MDM2/4 to inhibit expression, counteracting MDM2/4-mediated p53 signaling suppression and modulating RB cell proliferation and apoptosis.
Retinoblastoma (RB) is commonly-seen cancer in children. The p53 pathway dysfunction, which can lead to elevated MDM2 or MDM4 (p53 antagonists) protein expression, is frequently observed in almost all human cancers, including RB. The present study attempted to investigate the underlying mechanism from the perspective of non-coding RNA regulation. Here, we demonstrated that p53 and miR-129 were positively correlated with each other in RB. miR-129 directly targeted MDM2/4 to inhibit expression, therefore counteracting MDM2/4-mediated p53 signaling suppression and modulating RB cell proliferation and apoptosis. Moreover, p53 could activate the transcription of miR-129 via binding to the miR-129 promoter region, therefore forming a regulatory loop with MDM2/4 to affect RB progression. Altogether, the p53/miR-129/MDM2/4/p53 regulatory loop can modulate RB cell growth. We provide a solid experimental basis for developing novel therapies for RB.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据