Regulation of chromatin structure and function: insights into the histone chaperone FACT

In eukaryotic cells, changes in chromatin accessibility are necessary for chromatin to maintain its highly dynamic nature at different times during the cell cycle. Histone chaperones interact with histones and regulate chromatin dynamics. Facilitates chromatin transcription (FACT) is an important histone chaperone that plays crucial roles during various cellular processes. Here, we analyze the structural characteristics of FACT, discuss how FACT regulates nucleosome/chromatin reorganization and summarize possible functions of FACT in transcription, replication, and DNA repair. The possible involvement of FACT in cell fate determination is also discussed.

Automated summary

This article discusses the important role of the histone chaperone facilitates chromatin transcription (FACT) in the cell cycle, analyzing its structural characteristics and functions. It explores how FACT regulates chromatin reorganization and its potential roles in transcription, replication, DNA repair, and even cell fate determination.