An open pore structure of the Orai channel, finally

Store-operated Orai channels are a primary mechanism for mobilizing Ca2+ signals in both non-excitable cells and excitable cells. The structure of the open channel, vital for understanding the mechanism of channel opening, is incompletely understood. We highlight a new study that unveils the structure of a constitutively active Orai mutant and takes us closer towards understanding the molecular basis of Orai channel activation.

Automated summary

Store-operated Orai channels play a crucial role in mobilizing Ca2+ signals in cells. Understanding the structure of open channels is vital for unraveling the mechanism of channel activation. A new study discussed in the article brings us closer to understanding the molecular basis of Orai channel activation through unveiling the structure of a constitutively active Orai mutant.