期刊
CELL AND TISSUE RESEARCH
卷 384, 期 2, 页码 231-240出版社
SPRINGER
DOI: 10.1007/s00441-021-03414-x
关键词
Induced pluripotent stem cells; Tissue engineering; iPSC-derived cardiomyocytes; Cardiac regenerative medicine; Cell sheets; 3D bioprinting
类别
资金
- Zhejiang Provincial Science and Technology Projects [GF20H020041]
- Hangzhou Medical Technology Plan Project [0020190129]
Cardiovascular diseases are the leading cause of death worldwide, and regenerative medicine offers promising treatments. However, current cardiac cell therapies require further optimization for improved effectiveness.
Cardiovascular diseases are the leading cause of death in the world due to the high incidence of the diseases coupled with the limited therapeutic options. In recent years, advances in regenerative medicine have emerged as a promising treatment. Differentiation of induced pluripotent stem cells (iPSCs) into cardiac cells and emerging technologies allowing arrangement of cells into complex 3D tissue-like structures open new frontiers for transplantation and engraftment of these tissue patches onto the damaged heart. Despite the cells integrating and presenting initial neovascularization, the functional and electric properties of these patches are still not comparable with those of the host cardiac tissue. Future research optimizing maturation and integration of the iPSC-derived cardiomyocytes is paramount for cardiac cell therapy to attain clinical use. Herein, we will review the state of the art and the different approaches to constructing these 3D transplantable structures.
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