期刊
BONE
卷 81, 期 -, 页码 733-738出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2015.03.013
关键词
Histone modifications; DNA methylation; Intanuclear domains; RUNX2 epigenetics; Mitotic bookmarking
资金
- FONDAP [15090007]
- FONDECYT [1130706]
- NIH/NCI [PO1 CA082834, R03 CA167726]
- NIH [R01 AR039588]
- VCC/LCCRO Program Grants
Multiple dimensions of epigenetic control contribute to regulation of gene expression that governs bone biology and pathology. Once confined to DNA methylation and a limited number of post-translational modifications of histone proteins, the definition of epigenetic mechanisms is expanding to include contributions of non-coding RNAs and mitotic bookmarking, a mechanism for retaining phenotype identity during cell proliferation. Together these different levels of epigenetic control of physiological processes and their perturbations that are associated with compromised gene expression during the onset and progression of disease, have contributed to an unprecedented understanding of the activities (operation) of the genomic landscape. Here, we address general concepts that explain the contribution of epigenetic control to the dynamic regulation of gene expression during eukaryotic transcription. This article is part of a Special Issue entitled Epigenetics and Bone. (C) 2015 Elsevier Inc. All rights reserved.
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