期刊
EMBO REPORTS
卷 17, 期 11, 页码 1516-1531出版社
WILEY
DOI: 10.15252/embr.201643030
关键词
cancer; non-oncogene addiction; synthetic lethality; therapy; vulnerability
资金
- Dutch Cancer Society
- ERC Synergy Project CombatCancer
Historically, cancers have been treated with chemotherapeutics aimed to have profound effects on tumor cells with only limited effects on normal tissue. This approach was followed by the development of small-molecule inhibitors that can target oncogenic pathways critical for the survival of tumor cells. The clinical targeting of these so-called oncogene addictions, however, is in many instances hampered by the outgrowth of resistant clones. More recently, the proper functioning of non-mutated genes has been shown to enhance the survival of many cancers, a phenomenon called non-oncogene addiction. In the current review, we will focus on the distinct non-oncogenic addictions found in cancer cells, including synthetic lethal interactions, the underlying stress phenotypes, and arising therapeutic opportunities.
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