期刊
EMBO REPORTS
卷 17, 期 6, 页码 800-810出版社
WILEY
DOI: 10.15252/embr.201541108
关键词
endoplasmic reticulum; lipid transfer proteins; membrane contact sites; mitochondria; ORP
资金
- Marie Curie CIG [PCIG14-GA-2013-631202-ERPM]
- ANR Jeune Chercheur [ANR-14-CE11-0015]
- FWO [G0584.12N, GA01111N]
- KU Leuven [C16/15/073]
- Agence Nationale de la Recherche (ANR) [ANR-14-CE11-0015] Funding Source: Agence Nationale de la Recherche (ANR)
The oxysterol-binding protein (OSBP)-related proteins ORP5 and ORP8 have been shown recently to transport phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM) at ER-PM contact sites. PS is also transferred from the ER to mitochondria where it acts as precursor for mitochondrial PE synthesis. Here, we show that, in addition to ER-PM contact sites, ORP5 and ORP8 are also localized to ER-mitochondria contacts and interact with the outer mitochondrial membrane protein PTPIP51. A functional lipid transfer (ORD) domain was required for this localization. Interestingly, ORP5 and ORP8 depletion leads to defects in mitochondria morphology and respiratory function.
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