4.7 Review

Immuno-metabolic interfaces in cardiac disease and failure

期刊

CARDIOVASCULAR RESEARCH
卷 118, 期 1, 页码 37-52

出版社

OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvab036

关键词

Cardiac disease; Metabolism; Inflammation; Heart failure

资金

  1. Federal Ministry of Education and Research for the Comprehensive Heart Failure Center (BMBF) [01EO1504]
  2. German Research Foundation [Deutsche Forschungsgemeinschaft (DFG)] [374031971-TRR 240, 324392634-TR221, ZE827/13-1, ZE827/14-1, ZE827/16-1]
  3. Interdisciplinary Center for Clinical Research [Interdisziplinares Zentrum fur Klinische Forschung (IZKF)], University Hospital Wurzburg [E-352, A-384, IZKF-E-353]
  4. German Research Foundation (DFG) [Ma 2528/7-1, SFB 894, TRR 219, DU1839/2-1, HO5343/5]
  5. Barth Syndrome Foundation

向作者/读者索取更多资源

The interplay between the cardiovascular system, metabolism, and inflammation plays a central role in the pathophysiology of cardiovascular diseases. This paper provides an overview of the interrelation between inflammation and metabolism, discusses the involvement of disrupted immuno-metabolic interface in cardiovascular disease, and presents new technologies and therapeutic approaches.
The interplay between the cardiovascular system, metabolism, and inflammation plays a central role in the pathophysiology of a wide spectrum of cardiovascular diseases, including heart failure. Here, we provide an overview of the fundamental aspects of the interrelation between inflammation and metabolism, ranging from the role of metabolism in immune cell function to the processes how inflammation modulates systemic and cardiac metabolism. Furthermore, we discuss how disruption of this immuno-metabolic interface is involved in the development and progression of cardiovascular disease, with a special focus on heart failure. Finally, we present new technologies and therapeutic approaches that have recently emerged and hold promise for the future of cardiovascular medicine.

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