期刊
CARBOHYDRATE POLYMERS
卷 256, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.117418
关键词
Konjac glucomannan (KGM); Constipation; Different gastrointestinal tract microbiota; regulation; Mouse model; Different gastrointestinal tract microbiota regulation
资金
- Fundamental Research Funds for the Central Universities [XDJK2020D031]
- Southwest University [XYDS201905]
- Chongqing Joint Implementation of Key RD Projects [20ZDYF3632]
Konjac glucomannan dietotherapy can improve the physiological state and microbiota diversity of constipated mice, bringing them closer to the normal group.
Constipation is one of the most prevalent gastrointestinal tract diseases. Konjac glucomannan (KGM) dietotherapy can effectively relieve the clinical symptoms of patients with constipation. However, the causal relationship among KGM, constipation and different gastrointestinal microbiome (i.e., the stomach {St}, small intestine {S}, and large intestine {L}) remains poorly understood. In this study, constipated mice were treated with KGM (75, 150, 300 mg/kg bw). Results showed that KGM treatment improved the general physiological state, fecal character, small intestinal propulsive rate, gastric emptying rate, MTL and AchE activities, ET-1, 5 HT, and NO levels, and SCFA concentrations. KGM in the diets of constipated mice reduced the diversity of St and S microbiota, while increased those in the L. The KGM intervention regulated the microbiota profile, which afterwards was closer to the normal mouse group: confirmation was provided by different changes of bacteria like Lactobacillus, Bifidobacterium and Allobaculum spp et al.
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