期刊
CANCER SCIENCE
卷 112, 期 4, 页码 1417-1428出版社
WILEY
DOI: 10.1111/cas.14835
关键词
axitinib; CAR‐ T cells; c‐ met; orthotopic model; papillary renal cell carcinoma
类别
资金
- Japan Society for the Promotion of Science [(C) / 18K07268]
"This study demonstrated the potential clinical application of anti-c-met CAR-T cells in the treatment of patients with papillary renal cell carcinoma, showing synergistically augmented anti-tumor efficacy when combined with axitinib."
Chimeric antigen receptor (CAR)-T cell therapy has shown salient efficacy in cancer immunotherapy, particularly in the treatment of B cell malignancies. However, the efficacy of CAR-T for solid tumors remains inadequate. In this study, we displayed that c-met is an appropriate therapeutic target for papillary renal cell carcinoma (PRCC) using clinical samples, developed an anti-human c-met CAR-T cells, and investigated the anti-tumor efficacy of the CAR-T cells using an orthotopic mouse model as pre-clinical research. Administration of the anti-c-met CAR-T cells induced marked infiltration of the CAR-T cells into the tumor tissue and unambiguous suppression of tumor growth. Furthermore, in combination with axitinib, the anti-tumor efficacy of the CAR-T cells was synergistically augmented. Taken together, our current study demonstrated the potential for clinical application of anti-c-met CAR-T cells in the treatment of patients with PRCC.
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