相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models
Betty Y. Tam et al.
CANCER LETTERS (2020)
Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization
Vittoria Pagliarini et al.
NUCLEIC ACIDS RESEARCH (2020)
ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin
Iris Tanaka et al.
NUCLEIC ACIDS RESEARCH (2020)
Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development
Sze Jing Tang et al.
NATURE COMMUNICATIONS (2020)
Splicing factor proline- and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity
Ilenia Pellarin et al.
ONCOGENE (2020)
Heterogeneous nuclear ribonucleoprotein (hnRNPL) in cancer
Jingyao Gu et al.
CLINICA CHIMICA ACTA (2020)
Alternative Splicing by NOVA Factors: From Gene Expression to Cell Physiology and Pathology
Jacopo Meldolesi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
The HNRNPA2B1-MST1R-Akt axis contributes to epithelial-to-mesenchymal transition in head and neck cancer
Amit Gupta et al.
LABORATORY INVESTIGATION (2020)
Combined SRPK and AKT pharmacological inhibition is synergistic in T-cell acute lymphoblastic leukemia cells
Raoni Pais Siqueira et al.
TOXICOLOGY IN VITRO (2020)
The role of alternative splicing in cancer: From oncogenesis to drug resistance
Rocco Sciarrillo et al.
DRUG RESISTANCE UPDATES (2020)
Starvation-induced suppression of DAZAP1 by miR-10b integrates splicing control into TSC2-regulated oncogenic autophagy in esophageal squamous cell carcinoma
Yunsong Chen et al.
THERANOSTICS (2020)
Skipping of exon 10 in Axl pre-mRNA regulated by PTBP1 mediates invasion and metastasis process of liver cancer cells
Lianghua Shen et al.
THERANOSTICS (2020)
E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing
De Chen et al.
THERANOSTICS (2020)
SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer
Ledong Wan et al.
GUT (2019)
A Coiled-Coil Domain Containing 50 Splice Variant Is Modulated by Serine/Arginine-Rich Splicing Factor 3 and Promotes Hepatocellular Carcinoma in Mice by the Ras Signaling Pathway
Hong Wang et al.
HEPATOLOGY (2019)
Changes in mechanoreceptors in rabbits' anterior cruciate ligaments with age
Bin Li et al.
JOURNAL OF MOLECULAR HISTOLOGY (2019)
Integrative transcriptomic analysis suggests new autoregulatory splicing events coupled with nonsense-mediated mRNA decay
Dmitri Pervouchine et al.
NUCLEIC ACIDS RESEARCH (2019)
Oncogenic splicing factor SRSF3 regulates ILF3 alternative splicing to promote cancer cell proliferation and transformation
Rong Jia et al.
RNA (2019)
Post-translational modification control of RNA-binding protein hnRNPK function
Yongjie Xu et al.
OPEN BIOLOGY (2019)
Polypyrimidine tract binding protein 1 promotes lymphatic metastasis and proliferation of bladder cancer via alternative splicing of MEIS2 and PKM
Ruihui Xie et al.
CANCER LETTERS (2019)
Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells
Qianjing Zhang et al.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)
A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing
Francesca Angiolini et al.
ELIFE (2019)
DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing
Songge Xing et al.
CANCER RESEARCH (2019)
Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA
Xiao-Juan Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
PTBP1 mRNA isoforms and regulation of their translation
Luisa M. Arake de Tacca et al.
RNA (2019)
Downregulation of SRSF3 by antisense oligonucleotides sensitizes oral squamous cell carcinoma and breast cancer cells to paclitaxel treatment
Yanan Sun et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2019)
SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes
Xiao Song et al.
CANCER RESEARCH (2019)
HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction
Carla Neckles et al.
RNA (2019)
Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer
Jennifer Munkley et al.
ELIFE (2019)
Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis
Dongqin Yang et al.
EBIOMEDICINE (2019)
Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis
SungHee Park et al.
CELL REPORTS (2019)
SRSF1 and RBM4 differentially modulate the oncogenic effect of HIF-1α in lung cancer cells through alternative splicing mechanism
Huai-Liang Chang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)
Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways
Yesim Gokmen-Polar et al.
EMBO REPORTS (2019)
O-GlcNAc-induced nuclear translocation of hnRNP-K is associated with progression and metastasis of cholangiocarcinoma
Chatchai Phoomak et al.
MOLECULAR ONCOLOGY (2019)
Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma
Rocco Sciarrillo et al.
EBIOMEDICINE (2019)
Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression
Xiaomei Gao et al.
CLINICAL CANCER RESEARCH (2019)
PCBP1 inhibits the expression of oncogenic STAT3 isoform by targeting alternative splicing of STAT3 exon 23
Xiaole Wang et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)
HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition
Keiichiro Sakuma et al.
GUT (2018)
Placental growth factor signaling regulates isoform splicing of vascular endothelial growth factor A in the control of lung cancer cell metastasis
Zanfeng Wang et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2018)
PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing
Xinjun Ji et al.
NUCLEIC ACIDS RESEARCH (2018)
The AU-rich element landscape across human transcriptome reveals a large proportion in introns and regulation by ELAVL1/HuR
Tala Bakheet et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2018)
RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell
Jung-Chun Lin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)
The role of alternative splicing in cancer drug resistance
Zahava Siegfried et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2018)
Prognostic significance of SRSF2 mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia: a meta-analysis
Pourya Arbab Jafari et al.
HEMATOLOGY (2018)
Mesenchymal splice isoform of CD44 (CD44s) promotes EMT/invasion and imparts stem-like properties to ovarian cancer cells
Rahul Bhattacharya et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2018)
SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis
Fei Liu et al.
ONCOGENE (2018)
Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3
Hao Ke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
ECD promotes gastric cancer metastasis by blocking E3 ligase ZFP91-mediated hnRNP F ubiquitination and degradation
Song-Hui Xu et al.
CELL DEATH & DISEASE (2018)
SALL4-KHDRBS3 network enhances stemness by modulating CD44 splicing in basal-like breast cancer
Yoshiaki Matsumoto et al.
CANCER MEDICINE (2018)
HNRNPH1 is required for rhabdomyosarcoma cell growth and survival
Yanfeng Li et al.
ONCOGENESIS (2018)
MYC Regulates α6 Integrin Subunit Expression and Splicing Under Its Pro-Proliferative ITGA6A Form in Colorectal Cancer Cells
Jean-Francois Groulx et al.
CANCERS (2018)
Cancer-Associated MORC2-Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer
Fang-Lin Zhang et al.
CANCER RESEARCH (2018)
Antimetastatic effect of the pharmacological inhibition of serine/arginine-rich protein kinases (SRPK) in murine melanoma
Gabriela Alves Moreira et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)
NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
Andrew T. Ludlow et al.
NATURE COMMUNICATIONS (2018)
An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer
Ji Li et al.
ELIFE (2018)
SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells
Yuki Kuranaga et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Aberrant RNA Splicing in Cancer and Drug Resistance
Bi-Dar Wang et al.
CANCERS (2018)
SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
John M. Hatcher et al.
CELL CHEMICAL BIOLOGY (2018)
MBNL1 alternative splicing isoforms play opposing roles in cancer
Tommaso Tabaglio et al.
LIFE SCIENCE ALLIANCE (2018)
Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation
Pushkar Malakar et al.
CANCER RESEARCH (2017)
HnRNPM and CD44s expression affects tumor aggressiveness and predicts poor prognosis in breast cancer with axillary lymph node metastases
Huizhi Sun et al.
GENES CHROMOSOMES & CANCER (2017)
The role of RNA alternative splicing in regulating cancer metabolism
Itamar Kozlovski et al.
HUMAN GENETICS (2017)
RNA splicing and splicing regulator changes in prostate cancer pathology
Jennifer Munkley et al.
HUMAN GENETICS (2017)
Natural antisense transcript TPM1-AS regulates the alternative splicing of tropomyosin I through an interaction with RNA-binding motif protein 4
Guo-Wei Huang et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)
Reverse the Resistance to PARP Inhibitors
Yevgeniy Kim et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)
Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action
Lindsay D. Smith et al.
INTERNATIONAL JOURNAL OF CANCER (2017)
SR proteins: To shuttle or not to shuttle, that is the question
Marie-Louise Hammarskjold et al.
JOURNAL OF CELL BIOLOGY (2017)
Redirecting SR Protein Nuclear Trafficking through an Allosteric Platform
Brandon E. Aubol et al.
JOURNAL OF MOLECULAR BIOLOGY (2017)
Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells
Ramakumar Tummala et al.
MOLECULAR CANCER THERAPEUTICS (2017)
TRA2A Promoted Paclitaxel Resistance and Tumor Progression in Triple-Negative Breast Cancers via Regulating Alternative Splicing
Tieju Liu et al.
MOLECULAR CANCER THERAPEUTICS (2017)
The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1
Ji-Hang Yuan et al.
NATURE CELL BIOLOGY (2017)
A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression
Simon Grelet et al.
NATURE CELL BIOLOGY (2017)
Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy
David R. Corey
NATURE NEUROSCIENCE (2017)
Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS
Sarah J. Ross et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers
Jing Chen et al.
CANCER DISCOVERY (2017)
Eteplirsen in the treatment of Duchenne muscular dystrophy
Kenji Rowel Q. Lim et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2017)
HnRNPK/miR-223/FBXW7 feedback cascade promotes pancreatic cancer cell growth and invasion
De He et al.
ONCOTARGET (2017)
SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing
Linlin Chen et al.
CELL REPORTS (2017)
Emerging roles of hnRNPA1 in modulating malignant transformation
Rajat Roy et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2017)
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
Gina Lee et al.
CELL (2017)
Neuro-oncological ventral antigen 1 (NOVA1): Implications in neurological diseases and cancers
Yu Xin et al.
CELL PROLIFERATION (2017)
SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development
Chunling Luo et al.
CANCER RESEARCH (2017)
Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7: Implications for Racial Disparity of Prostate Cancer
Yijun Yang et al.
CLINICAL CANCER RESEARCH (2016)
Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth
Michael Dewaele et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells
S. Calabretta et al.
ONCOGENE (2016)
Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease
Paola Briata et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA (2016)
Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia
Lili Wang et al.
CANCER CELL (2016)
The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin
Yifan Wang et al.
CANCER RESEARCH (2016)
microRNAs target SRSF7 splicing factor to modulate the expression of osteopontin splice variants in renal cancer cells
Joanna Boguslawska et al.
GENE (2016)
Characterization of the Regulation of CD46 RNA Alternative Splicing
Sze Jing Tang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
Wen Xiao et al.
MOLECULAR CELL (2016)
A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer
Fernando J. de Miguel et al.
MOLECULAR ONCOLOGY (2016)
Multiple determinants of splicing repression activity in the polypyrimidine tract binding proteins, PTBP1 and PTBP2
Niroshika M. Keppetipola et al.
RNA (2016)
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
Feimeng Zheng et al.
NATURE COMMUNICATIONS (2016)
Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
Samar Alsafadi et al.
NATURE COMMUNICATIONS (2016)
Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells
Isabel Meininger et al.
NATURE COMMUNICATIONS (2016)
Splicing factor mutations predict poor prognosis in patients with de novo acute myeloid leukemia
Hsin-An Hou et al.
ONCOTARGET (2016)
SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors
Lulzim Shkreta et al.
CELL REPORTS (2016)
RNA-binding protein hnRNPLL as a critical regulator of lymphocyte homeostasis and differentiation
Xing Chang
WILEY INTERDISCIPLINARY REVIEWS-RNA (2016)
Angiopoietin-2: marker or mediator of angiogenesis in continuous-flow left ventricular assist device patients?
Lauren K. Truby et al.
JOURNAL OF THORACIC DISEASE (2016)
HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endometrial cancer
Marc Hirschfeld et al.
BMC CANCER (2015)
The RNA Binding Protein Quaking Regulates Formation of circRNAs
Simon J. Conn et al.
CELL (2015)
NF-kappa B2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer
Nagalakshmi Nadiminty et al.
MOLECULAR CANCER THERAPEUTICS (2015)
SRSF1-Regulated Alternative Splicing in Breast Cancer
Olga Anczukow et al.
MOLECULAR CELL (2015)
TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways
Laura De Conti et al.
NUCLEIC ACIDS RESEARCH (2015)
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities
Jian Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
SRSF3 and hnRNP H1 regulate a splicing hotspot of HER2 in breast cancer cells
Hannah Gautrey et al.
RNA BIOLOGY (2015)
AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer
David Hong et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Bortezomib inhibits Burkitt's lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression
Fat-Moon Suk et al.
ONCOTARGET (2015)
The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells
Yu-Chih Liang et al.
ONCOTARGET (2015)
Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point
Rachel B. Darman et al.
CELL REPORTS (2015)
SAM68: Signal Transduction and RNA Metabolism in Human Cancer
Paola Frisone et al.
BIOMED RESEARCH INTERNATIONAL (2015)
Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3′ UTR of BCL2 mRNA
Y. Kuwano et al.
CELL DEATH AND DIFFERENTIATION (2015)
Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance
Maryarn A. Hamdollah Zadeh et al.
MOLECULAR ONCOLOGY (2015)
Glycosylation in cancer: mechanisms and clinical implications
Salome S. Pinho et al.
NATURE REVIEWS CANCER (2015)
Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation
Luciana O. Almeida et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression
Yang Wang et al.
CANCER CELL (2014)
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
Xu Zhao et al.
CELL RESEARCH (2014)
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing
Yilin Xu et al.
GENES & DEVELOPMENT (2014)
PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis
Xuehui Hong et al.
GUT (2014)
HuR and TIA1/TIAL1 Are Involved in Regulation of Alternative Splicing of SIRT1 Pre-mRNA
Wenhui Zhao et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors
D. S. Hong et al.
INVESTIGATIONAL NEW DRUGS (2014)
Coherence between Cellular Responses and in Vitro Splicing Inhibition for the Anti-tumor Drug Pladienolide B and Its Analogs
Kerstin A. Effenberger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Chemical Proteomics Identifies Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A1 as the Molecular Target of Quercetin in Its Anti-cancer Effects in PC-3 Cells
Chia-Chen Ko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The HER2 Signaling Network in Breast Cancer-Like a Spider in its Web
A. Dittrich et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2014)
An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease
Ryosuke Kikuchi et al.
NATURE MEDICINE (2014)
AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer
Emmanuel S. Antonarakis et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival
Chiara Naro et al.
NUCLEIC ACIDS RESEARCH (2014)
A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy
Chao Liu et al.
NUCLEIC ACIDS RESEARCH (2014)
Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection
Pamela Bielli et al.
NUCLEIC ACIDS RESEARCH (2014)
Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells
K. Kurokawa et al.
ONCOGENE (2014)
SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNA
Tiing Jen Loh et al.
ONCOLOGY REPORTS (2014)
CD44 variant 6 is associated with prostate cancer metastasis and chemo-/radioresistance
Jie Ni et al.
PROSTATE (2014)
Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events
Jung-Chun Lin et al.
RNA (2014)
BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells
Xuexia Zhou et al.
NATURE COMMUNICATIONS (2014)
RBM4-REGULATED ALTERNATIVE SPLICING SUPPRESSES TUMORIGENESIS
[Anonymous]
CANCER DISCOVERY (2014)
Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells
Yang Gao et al.
SCIENTIFIC REPORTS (2014)
The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing
Feng-Yang Zong et al.
PLOS GENETICS (2014)
Chemical Perturbation of Mcl-1 Pre-mRNA Splicing to Induce Apoptosis in Cancer Cells
Yang Gao et al.
ACS CHEMICAL BIOLOGY (2013)
The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis
Imke Listerman et al.
CANCER RESEARCH (2013)
Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors
Ferry A. L. M. Eskens et al.
CLINICAL CANCER RESEARCH (2013)
Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma
Zheng-Jun Zhou et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
The splicing factor SRSF6 is amplified and is an oncoprotein inlung and colon cancers
Michal Cohen-Eliav et al.
JOURNAL OF PATHOLOGY (2013)
RBM5, 6, and 10 Differentially Regulate NUMB Alternative Splicing to Control Cancer Cell Proliferation
Elias G. Bechara et al.
MOLECULAR CELL (2013)
Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway
L. Adesso et al.
ONCOGENE (2013)
Par-4/THAP1 complex and Notch3 competitively regulated pre-mRNA splicing of CCAR1 and affected inversely the survival of T-cell acute lymphoblastic leukemia cells
C. Lu et al.
ONCOGENE (2013)
Detection of VEGF-Axxxb Isoforms in Human Tissues
David O. Bates et al.
PLOS ONE (2013)
Neutralization of terminal differentiation in gliomagenesis
Jian Hu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Mechanisms of Action of Bcl-2 Family Proteins
Aisha Shamas-Din et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1
Vered Ben-Hur et al.
CELL REPORTS (2013)
SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases
Sebastian Oltean et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2012)
Solution Structure of the Second RRM Domain of RBM5 and Its Unusual Binding Characters for Different RNA Targets
Zhenwei Song et al.
BIOCHEMISTRY (2012)
Disruption of the VDAC2-Bak interaction by Bcl-xS mediates efficient induction of apoptosis in melanoma cells
M. Ploetz et al.
CELL DEATH AND DIFFERENTIATION (2012)
SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage
Seong Won Lee et al.
EMBO JOURNAL (2012)
DNA Damage-induced Heterogeneous Nuclear Ribonucleoprotein K SUMOylation Regulates p53 Transcriptional Activation
Federico Pelisch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
VEGF gene alternative splicing: pro- and anti-angiogenic isoforms in cancer
P. M. Biselli-Chicote et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2012)
Hepatocyte Growth Factor Enhances Alternative Splicing of the Kruppel-like Factor 6 (KLF6) Tumor Suppressor to Promote Growth through SRSF1
Ursula Munoz et al.
MOLECULAR CANCER RESEARCH (2012)
The spliceosome as a target of novel antitumour drugs
Sophie Bonnal et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1
Chiranthani Sumanasekera et al.
NUCLEIC ACIDS RESEARCH (2012)
HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing
Marco Preussner et al.
NUCLEIC ACIDS RESEARCH (2012)
Binding of the Heterogeneous Ribonucleoprotein K (hnRNP K) to the Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) Enhances Viral LMP2A Expression
Henrik Gross et al.
PLOS ONE (2012)
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell
Toshifumi Yae et al.
NATURE COMMUNICATIONS (2012)
Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC
Shipra Das et al.
CELL REPORTS (2012)
Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides
Zhenxun Wang et al.
OPEN BIOLOGY (2012)
Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease
Gerald W. Hart et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing
Elianna M. Amin et al.
CANCER CELL (2011)
c-Myc Regulates RNA Splicing of the A-Raf Kinase and Its Activation of the ERK Pathway
Jens Rauch et al.
CANCER RESEARCH (2011)
Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer
Zhi-Yu Chen et al.
CARCINOGENESIS (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
SRSF2 is required for sodium butyrate-mediated p21WAF1 induction and premature senescence in human lung carcinoma cell lines
Valerie Edmond et al.
CELL CYCLE (2011)
Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin
Valerie Edmond et al.
EMBO JOURNAL (2011)
Phosphorylation mechanism and structure of serine-arginine protein kinases
Gourisankar Ghosh et al.
FEBS JOURNAL (2011)
Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1
Hitomi Tsuiji et al.
GENES TO CELLS (2011)
Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor
Kensuke Ninomiya et al.
JOURNAL OF CELL BIOLOGY (2011)
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
Rhonda L. Brown et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Proteomic analysis of 1α,25-Dihydroxyvitamin D3 action on human colon cancer cells reveals a link to splicing regulation
Ivan Cristobo et al.
JOURNAL OF PROTEOMICS (2011)
QKI-Mediated Alternative Splicing of the Histone Variant MacroH2A1 Regulates Cancer Cell Proliferation
Leonid Novikov et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Analysis of in situ pre-mRNA targets of human splicing factor SF1 reveals a function in alternative splicing
Margherita Corioni et al.
NUCLEIC ACIDS RESEARCH (2011)
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
Michelle C. Mendoza et al.
TRENDS IN BIOCHEMICAL SCIENCES (2011)
Alternative Splicing of the Cyclin D1 Proto-Oncogene Is Regulated by the RNA-Binding Protein Sam68
Maria Paola Paronetto et al.
CANCER RESEARCH (2010)
Identification of ASF/SF2 as a Critical, Allele-Specific Effector of the Cyclin D1b Oncogene
Nicholas A. Olshavsky et al.
CANCER RESEARCH (2010)
An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis
Michael J. Moore et al.
CELL (2010)
Does interference between replication and transcription contribute to genomic instability in cancer cells?
Sandie Tuduri et al.
CELL CYCLE (2010)
The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy
Simona Pedrotti et al.
EMBO JOURNAL (2010)
Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms A NOVEL THERAPEUTIC STRATEGY FOR ANGIOGENESIS
Dawid G. Nowak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Arginine Methylation Controls the Subcellular Localization and Functions of the Oncoprotein Splicing Factor SF2/ASF
Rahul Sinha et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation
Vidisha Tripathi et al.
MOLECULAR CELL (2010)
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
Charles J. David et al.
NATURE (2010)
Anti-tumor activity of splice-switching oligonucleotides
John A. Bauman et al.
NUCLEIC ACIDS RESEARCH (2010)
The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo
G. Merdzhanova et al.
ONCOGENE (2010)
Oxidative stress-induced alternative splicing of transformer 2β (SFRS10) and CD44 pre-mRNAs in gastric epithelial cells
Keiko Takeo et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
The SR protein family of splicing factors: master regulators of gene expression
Jennifer C. Long et al.
BIOCHEMICAL JOURNAL (2009)
AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines
Dana S. Levy et al.
BLOOD (2009)
MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53
Martin Enge et al.
CANCER CELL (2009)
Interaction of Akt-phosphorylated SRPK2 with 14-3-3 Mediates Cell Cycle and Cell Death in Neurons
Sung-Wuk Jang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Heterogeneous Nuclear Ribonucleoprotein K Represses the Production of Pro-apoptotic Bcl-xS Splice Isoform
Timothee Revil et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements
Hai Li et al.
JOURNAL OF LIPID RESEARCH (2009)
Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping
Yuanchao Xue et al.
MOLECULAR CELL (2009)
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5′ splice site-like sequences
Fionna E. Loughlin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Chunaram Choudhary et al.
SCIENCE (2009)
Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation
Alex N. Bullock et al.
STRUCTURE (2009)
Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54nrb
Taiji Ito et al.
BIOCHEMICAL JOURNAL (2008)
The ratio of ±KTS splice variants of the Wilms' tumour suppressor protein WT1 mRNA is determined by an intronic enhancer
Cheng Yang et al.
BIOCHEMISTRY AND CELL BIOLOGY (2008)
E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35
G. Merdzhanova et al.
CELL DEATH AND DIFFERENTIATION (2008)
Arginine methylation of hnRNP K enhances p53 transcriptional activity
Yibin Chen et al.
FEBS LETTERS (2008)
Antagonistic effects of the SRp30c protein and cryptic 5′ splice sites on the alternative splicing of the apoptotic regulator Bcl-x
Philippe Cloutier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition
Jose M. Izquierdo
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Negative and positive mRNA splicing elements act competitively to regulate human immunodeficiency virus type 1 Vif gene expression
C. M. Exline et al.
JOURNAL OF VIROLOGY (2008)
Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5′ splice site selection
AnYu Zhou et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Alternative isoform regulation in human tissue transcriptomes
Eric T. Wang et al.
NATURE (2008)
HITS-CLIP yields genome-wide insights into brain alternative RNA processing
Donny D. Licatalosi et al.
NATURE (2008)
Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1
Marianna Teplova et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5
Kazuo Fushimi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Increased expression of SRp40 affecting CD44 splicing is associated with the clinical outcome of lymph node metastasis in human breast cancer
Chiun-Sheng Huang et al.
CLINICA CHIMICA ACTA (2007)
Splicing factor SF3b as a target of the antitumor natural product pladienolide
Yoshihiko Kotake et al.
NATURE CHEMICAL BIOLOGY (2007)
The early response to DNA damage can lead to activation of alternative splicing activity resulting in CD44 splice pattern changes
Valery Filippov et al.
CANCER RESEARCH (2007)
Bombesin attenuates pre-mRNA splicing of glucocorticoid receptor by regulating the expression of serine-arginine protein p30c (SRp30c) in prostate cancer cells
Jin Zhu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Identification and characterization RED120:: A conserved PWI domain protein with links to splicing and 3'-end formation
Puri Fortes et al.
FEBS LETTERS (2007)
Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements
Liana F. Lareau et al.
NATURE (2007)
Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1
Qingchang Meng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay
Julie Z. Ni et al.
GENES & DEVELOPMENT (2007)
The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
Maria Paola Paronetto et al.
JOURNAL OF CELL BIOLOGY (2007)
RET oncoproteins induce tyrosine phosphorylation changes of proteins involved in RNA metabolism
L. Gorla et al.
CELLULAR SIGNALLING (2006)
WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo
M. Andrea Markus et al.
EXPERIMENTAL CELL RESEARCH (2006)
SAP155 binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5′ splice site selection of Bcl-x pre-mRNA
Autumn Massiello et al.
FASEB JOURNAL (2006)
Splicing factor Tra2-β1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene
Dirk O. Watermann et al.
CANCER RESEARCH (2006)
Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src
A Ostareck-Lederer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Casein kinases phosphorylate multiple residues spanning the entire hnRNP K length
M Mikula et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2006)
Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion
CH Cheng et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
hnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage
A Moumen et al.
CELL (2005)
X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids
PH Backe et al.
STRUCTURE (2005)
SUMO: A history of modification
RT Hay
MOLECULAR CELL (2005)
Consequences of regulated pre-mRNA splicing in the immune system
KW Lynch
NATURE REVIEWS IMMUNOLOGY (2004)
Identifying and quantifying in vivo methylation sites by heavy methyl SILAC
SE Ong et al.
NATURE METHODS (2004)
SUMO modification of heterogeneous nuclear ribonucleoproteins
MT Vassileva et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Regulation of NF-κB-dependent lymphocyte activation and development by paracaspase
AA Ruefli-Brasse et al.
SCIENCE (2003)
Pre-mRNA splicing: Awash in a sea of proteins
MS Jurica et al.
MOLECULAR CELL (2003)
SR protein expression and CD44 splicing pattern in human breast tumours
MT Pind et al.
BREAST CANCER RESEARCH AND TREATMENT (2003)
A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG
Y Jin et al.
EMBO JOURNAL (2003)
The RNA splicing factor topoisomerase I mediated SF/SF2 inhibits human DNA relaxation
FF Andersen et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Function of quaking in myelination:: Regulation of alternative splicing
JI Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9
E Buratti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Strong RNA splicing enhancers identified by a modified method of cycled selection interact with SR protein
HH Tian et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue
H Habelhah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Modification of alternative splicing of Bcl-x Pre-mRNA in prostate and breast cancer cells - Analysis of apoptosis and cell death
DR Mercatante et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation
A Aigner et al.
ONCOGENE (2001)
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation
H Habelhah et al.
NATURE CELL BIOLOGY (2001)