Normal Somatic Mutations in Cancer Transformation

Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.

Automated summary

Gene alterations play a crucial role in driving cancer initiation and progression, but the genetic events occurring in normal cells prior to tumorigenesis remain unknown. Recent studies have started mapping somatic mutations in normal human tissues, shedding light on our understanding of tumorigenesis.