期刊
CANCER CELL
卷 39, 期 2, 页码 125-129出版社
CELL PRESS
DOI: 10.1016/j.ccell.2020.11.002
关键词
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资金
- Cancer Research UK [C43634/A25487, FC001002]
- European Union [CONTRA-766030]
- Cancer Research UK King's Health Partners Centre at King's College London [C604/A25135]
- Cancer Research UK City of London Centre [C7893/A26233]
- King's College London
- Francis Crick Institute
- UK Medical Research Council [FC001002]
- Wellcome Trust [FC001002]
Gene alterations play a crucial role in driving cancer initiation and progression, but the genetic events occurring in normal cells prior to tumorigenesis remain unknown. Recent studies have started mapping somatic mutations in normal human tissues, shedding light on our understanding of tumorigenesis.
Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.
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