期刊
EMBO MOLECULAR MEDICINE
卷 8, 期 10, 页码 1120-1133出版社
WILEY
DOI: 10.15252/emmm.201606593
关键词
adjuvant; Fc gamma R; immune complex; immune therapy; vaccine
资金
- China National Science and Technology Major Project [2012ZX100020020042]
- joint Peking-Tsinghua Center for Life Sciences
- National Natural Science Foundation of China General Program [31370878]
- US NIH [R01AI098995]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-355350/396037]
- Canadian Institutes for Health Research [MOP-119295]
Clinical and experimental preparations of IgG/soluble antigen complexes, as well as those formed following antibody therapy in vivo, are multifaceted immune regulators. These immune complexes (ICs) have been tested in humans and animal models, mostly in forms of experimental or clinical vaccination, for at least a century. With intensified research on Fc gamma receptor-mediated immune modulation, as well as with immune complex-directed antigen processing, presentation, and inflammatory responses, there are renewed interests of using ICs in vaccines and immunotherapies. Currently, IC-based immune therapy has been broadly experimented in HBV and HIV viral infection control and antitumor treatments. However, mechanistic insights of IC-based treatments are relatively recent subjects of study; strong efforts are needed to establish links to connect laboratory findings with clinical practices. This review covers the history, mechanisms, and in vivo outcomes of this safe and effective therapeutic tool, with a clear aim to bridge laboratory findings with evolving clinical applications.
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