期刊
CANCER
卷 127, 期 7, 页码 1010-1020出版社
WILEY
DOI: 10.1002/cncr.33433
关键词
chimeric antigen receptor T cells (CAR T cells); cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitor; immunotherapy; mesothelin; mesothelioma; programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitor.
类别
资金
- Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research [Z01--BC--006150]
Malignant mesothelioma is an aggressive cancer with poor prognosis and limited treatment options. The recent approval of nivolumab plus ipilimumab as frontline treatment for patients with pleural mesothelioma represents a significant milestone in the management of this disease, highlighting the emerging use of immunotherapy and mesothelin-targeted therapies for advanced cases.
Malignant mesothelioma is an aggressive cancer with a poor prognosis and limited treatment options. For many years, the only US Food and Drug Administration-approved first-line treatment for unresectable mesothelioma was pemetrexed plus cisplatin. However, the recent approval of nivolumab plus ipilimumab as frontline treatment for patients with pleural mesothelioma marks a significant milestone for the treatment of this disease. In this review, the authors describe recent advances in therapeutic strategies for the treatment of patients with advanced, unresectable mesothelioma, highlighting the emerging use of immunotherapy and mesothelin-targeted therapies for the management of malignant mesothelioma.
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