期刊
EMBO MOLECULAR MEDICINE
卷 8, 期 8, 页码 937-948出版社
WILEY-BLACKWELL
DOI: 10.15252/emmm.201506083
关键词
circadian rhythm; fibrosis; myocardial infarction healing; neutrophils; progenitors
资金
- FoeFoLe (Foerderung von Forschung und Lehre) program of the Ludwig-Maximilians-University Munich
- Deutsche Forschungsgemeinschaft [STE-1053/5-1, 10876/6-1, SFB1123]
- Emmy-Noether grant [SCHE 1645/2-1, SFB 914]
- German Centre for Cardiovascular Research (DZHK MHA)
- European Research Council ERC [AdG 249929]
- NWO (VIDI project) [91712303]
- TransCard Ph.D. Fellowship (Helmholtz International Research School Translational Cardiovascular and Metabolic Medicine)
Myocardial infarction (MI) is the leading cause of death in Western countries. Epidemiological studies show acute MI to be more prevalent in the morning and to be associated with a poorer outcome in terms of mortality and recovery. The mechanisms behind this association are not fully understood. Here, we report that circadian oscillations of neutrophil recruitment to the heart determine infarct size, healing, and cardiac function after MI. Preferential cardiac neutrophil recruitment during the active phase (Zeitgeber time, ZT13) was paralleled by enhanced myeloid progenitor production, increased circulating numbers of CXCR2(hi) neutrophils as well as upregulated cardiac adhesion molecule and chemokine expression. MI at ZT13 resulted in significantly higher cardiac neutrophil infiltration compared to ZT5, which was inhibited by CXCR2 antagonism or neutrophil-specific CXCR2 knockout. Limiting exaggerated neutrophilic inflammation at this time point significantly reduced the infarct size and improved cardiac function.
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