期刊
BRITISH JOURNAL OF NUTRITION
卷 127, 期 1, 页码 35-54出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114521000817
关键词
Bioavailability; Deposition; n-3; very-long-chain PUFA
资金
- Research Council of Norway: DodreMarin [256446]
- Research Council of Norway: MarOmega3 [282233]
- Research Council of Norway: Health effects of marine VLC-fatty acids [310433]
- Innovation project in Norwegian Research Council [310433]
- Epax Norway AS (Aalesund, Norway)
This study investigated the bio-availability and deposition of n-3 VLC-PUFA from dietary sources in rat, fish, and mouse tissues. The findings suggest that these fatty acids can be provided through diet and are deposited in various tissues, with deposition patterns varying by tissue rather than species.
There is limited knowledge about the metabolism and function of n-3 very-long-chain PUFA (n-3 VLC-PUFA) with chain lengths >= 24. They are known to be produced endogenously in certain tissues from EPA and DHA and not considered to originate directly from dietary sources. The aim of this study was to investigate whether n-3 VLC-PUFA from dietary sources are bio-available and deposited in tissues of rat, fish and mouse. Rats were fed diets supplemented with a natural fish oil (FO) as a source of low dietary levels of n-3 VLC-PUFA, while Atlantic salmon and mice were fed higher dietary levels of n-3 VLC-PUFA from a FO concentrate. In all experiments, n-3 VLC-PUFA incorporation in organs was investigated. We found that natural FO, due to its high EPA content, to a limited extent increased endogenous production of n-3 VLC-PUFA in brain and eye of mice with neglectable amounts of n-3 VLC-PUFA originating from diet. When higher dietary levels were given in the form of concentrate, these fatty acids were bio-available and deposited in both phospholipids and TAG fractions of all tissues studied, including skin, eye, brain, testis, liver and heart, and their distribution appeared to be tissue-dependent, but not species-specific. When dietary EPA and DHA were balanced and n-3 VLC-PUFA increased, the major n-3 VLC-PUFA from the concentrate increased significantly in the organs studied, showing that these fatty acids can be provided through diet and thereby provide a tool for functional studies of these VLC-PUFA.
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