期刊
BRITISH JOURNAL OF NUTRITION
卷 126, 期 12, 页码 1888-1896出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114521000660
关键词
Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay diet; Left ventricular structure; Left ventricular function; Cardiac remodelling
资金
- NHLBI Multidisciplinary Training Program in Cardiovascular Epidemiology [5T32HL125232]
- PRIMER (Promoting Research In MEdical Residency program) [1R38HL143584]
- American Heart Association [20CDA35310237]
- NIH National Heart Lung and Blood Institute (NHLBI) Framingham Heart Study [NO1-HC-25195, HHSN268201500001I, 75N92019D00031, P20 HL113444, P30 DK020579]
- Evans Medical Foundation
- Jay and Louis Coffman Endowment from the Department of Medicine, Boston University School of Medicine
The study found an association between MIND diet score and cardiac remodelling, with varying effects on different indices of LV structure and function. This association may be influenced by cardiometabolic and lifestyle risk factors.
Normal cardiac function is directly associated with the maintenance of cerebrovascular health. Whether the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet, designed for the maintenance of neurocognitive health, is associated with cardiac remodelling is unknown. We evaluated 2512 Framingham Offspring Cohort participants who attended the eighth examination cycle and had available dietary and echocardiographic data (mean age 66 years; 55 % women). Using multivariable regression, we related the cumulative MIND diet score (independent variable) to left ventricular (LV) ejection fraction, left atrial emptying fraction, LV mass (LVM), E/e' ratio (dependent variables; primary), global longitudinal strain, global circumferential strain (GCS), mitral annular plane systolic excursion, longitudinal segmental synchrony, LV hypertrophy and aortic root diameter (secondary). Adjusting for age, sex and energy intake, higher cumulative MIND diet scores were associated with lower values of indices of LV diastolic (E/e' ratio: log beta = -0 center dot 03) and systolic function (GCS: beta = -0 center dot 04) and with higher values of LVM (log beta = 0 center dot 02), all P <= 0 center dot 01. We observed effect modification by age in the association between the cumulative MIND diet score and GCS. When we further adjusted for clinical risk factors, the associations of the cumulative MIND diet score with GCS in participants >= 66 years (beta = -0 center dot 06, P = 0 center dot 005) and LVM remained significant. In our community-based sample, relations between the cumulative MIND diet score and cardiac remodelling differ among indices of LV structure and function. Our results suggest that favourable associations between a higher cumulative MIND diet score and indices of LV function may be influenced by cardiometabolic and lifestyle risk factors.
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