The minor spliceosome could be the major key for FUS/TLS mutants in ALS

Despite its name, minor spliceosome alterations are often involved in human disease origin. Work by Reber etal () in this issue of The EMBO Journal now demonstrates a connection between minor spliceosome components and FUS/TLS, one of the major proteins aggregating in the brain of patients affected by amyotrophic lateral sclerosis (ALS). This finding has important implications as it extends the spectrum of diseases where minor spliceosome plays a role. It may also represent a new opportunity for specific therapeutic targets.