MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast

Postradiation cutaneous angiosarcoma of the breast is a rare, delayed complication of adjuvant radiation treatment for breast carcinoma and is associated with a worse prognosis than the original primary cancer. Recent studies have characterized the diagnostic utility of MYC and NOTCH1 receptor expression as markers for secondary radiation-associated angiosarcomas. Herein, we report an exophytic secondary breast angiosarcoma with MYC and NOTCH1 immunoreactivity. This case illustrates the utility of these markers for the identification of radiation-associated angiosarcoma with MYC and NOTCH1 expression, potential for targeted therapy and need to identify patients for further studies of the clinicopathologic and prognostic significance.

Automated summary

Postradiation cutaneous angiosarcoma of the breast is a rare complication associated with adjuvant radiation treatment for breast carcinoma, which has a worse prognosis than the primary cancer. Recent studies have shown that MYC and NOTCH1 receptor expression can serve as markers for secondary radiation-associated angiosarcomas.