期刊
BONE
卷 74, 期 -, 页码 146-152出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2015.01.015
关键词
Lean body mass; Fat mass; Body mass index; Bone mineral density; Middle-aged adults; Busselton Healthy Ageing Study
资金
- Office of Science
- Department of Health of the Government of Western Australia, the City of Busselton [G05911]
- NHMRC
Low BMI is a risk factor for osteoporosis, but it is not clear if relationships between BMI, lean mass (LM), fat mass (FM) and BMD are consistent across different levels of BMI. We studied 1929 Caucasian participants (1014 females) aged 45-66 years in the Busselton Healthy Ageing Study in Western Australia. Body composition and BMD of total body, lumbar spine, total hip and femoral neck were measured using DXA. From generalized additive models, the positive relationships between BMI and BMD were weaker at high BMI, particularly at the spine and in males. In the entire cohort adjusting for relevant covariates, LM and FM were significant predictors of all BMD measures in both genders. In men, analysis by tertiles of BMI showed that LM and FM (in kg) were positively associated with BMD (in mg/cm(2)) in tertile 1 except for LM and spine BMD (LM beta: 5.18-6.80, FM beta: 338-9.24, all P <0.05), but not in the middle or upper tertiles (LM beta: -3.12-3.07, FM beta: -4.75-1.82, P > 0.05). In women, LM was positively associated with BMD in each fertile of BMI, except for spine BMD in the upper tertile, with regression coefficients lower in the upper tertile (beta: 5.16-9.95, 5.76-9.56 and 2.80-5.78, respectively, all P< 0.05). FM was positively associated with total body, spine and total hip BMD in women in BMI tertile 1(beta: 2.86-6.68, P <0.05); these associations were weaker or absent in the middle and upper tertiles. In conclusion, in middle-aged adults the positive relationships between lean or fat mass with BMD among those with higher BMI are absent in males and weaker in females. (c) 2015 Elsevier Inc. All rights reserved.
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