Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis

BackgroundAlthough Respiratory syncytial virus (RSV) is one of the common pathogens in children with pertussis and viral coinfection, the clinical impact of RSV infection on pertussis remains unclear. We compared clinical characteristics and sought differences between infants with single Bordetella pertussis (B. pertussis) infection and those with RSV coinfection.MethodsWe enrolled 80 patients with pertussis who were hospitalized in Shenzhen Children's Hospital from January 2017 to December 2019. Respiratory tract samples were tested for B. pertussis with real-time polymerase chain reaction and respiratory viruses with immunofluorescence assay. Clinical data were obtained from hospital records and collected using a structured questionnaire.ResultsThirty-seven of 80 patients had B. pertussis infection alone (pertussis group) and 43 had RSV-pertussis coinfection (coinfection group). No significant differences were found with regard to sex, body weight, preterm birth history, pertussis vaccination, symptoms, presence of pneumonia, or lymphocyte count between the 2 groups. Univariate analysis showed patients with RSV coinfection were older (median, 4.57months vs 4.03months, p=0.048); more commonly treated with beta -lactam antibiotics (21% vs 5%, p=0.044); had higher rates of wheezes (40% vs 14%, p=0.009) and rales (35% vs 14%, p=0.028) on chest auscultation, a higher rate of readmission (40% vs 11%, p=0.004), and a longer hospital stay (median, 10days vs 7days, p=0.002). In the further binary logistic regression analysis, patients with RSV coinfection had higher rates of wheezes (OR=3.802; 95% CI: 1.106 to 13.072; p=0.034) and readmission (OR=5.835; 95% CI: 1.280 to 26.610; p=0.023).ConclusionsRSV coinfection increases readmission rate in children hospitalized for pertussis. RSV infection should be suspected when wheezes are present on auscultation of the chest in these patients. Early detection of RSV may avoid unnecessary antibiotic use.

Automated summary

This study compared infants with single Bordetella pertussis (B. pertussis) infection and those with RSV coinfection and found that RSV coinfection is associated with a higher readmission rate and longer hospital stay in children hospitalized for pertussis. Wheezes on chest auscultation should raise suspicion of RSV infection, and early detection may prevent unnecessary antibiotic use.