CHIPping away at Erdheim-Chester disease

In this issue of Blood, Cohen Aubart et al report a high prevalence (42.5%) of mutations associated with clonal hematopoiesis (CH) in bone marrow specimens of patients with Erdheim-Chester disease (ECD).(1) These novel findings shed light upon the molecular underpinnings of ECD and its well-known association with other myeloid neoplasms.

Automated summary

The study found a high prevalence of mutations associated with clonal hematopoiesis in patients with Erdheim-Chester disease, shedding light on the molecular mechanisms of ECD and its known association with other myeloid neoplasms.