期刊
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
卷 26, 期 1, 页码 25-38出版社
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
DOI: 10.1007/s12257-020-0383-0
关键词
viral nanoparticles (VNPs); self-assembly; anticancer; drug delivery; nanotechnology
资金
- Shandong Provincial Key Research and Development Program (International Science and Technology Cooperation) [2019GHZ033]
- International Science and Technology Cooperation Program of Shandong Academy of Sciences [2019GHPY05]
Viral nanoparticles are versatile building blocks and supra-molecular templates in nanotechnology, offering advantages such as biocompatibility, biodegradability, water solubility, and high uptake capability. They have been utilized for genetic and chemical manipulation, targeted drug delivery, and encapsulation of various payloads for diagnosis or therapeutic intervention.
Viral nanoparticles (VNPs) comprise a variety of mammalian viruses, plant viruses, and bacteriophages, that have been adopted as building blocks and supra-molecular templates in nanotechnology. VNPs demonstrate the dynamic, monodisperse, polyvalent, and symmetrical architectures which represent examples of such biological templates. These programmable scaffolds have been exploited for genetic and chemical manipulation for displaying of targeted moieties together with encapsulation of various payloads for diagnosis or therapeutic intervention. The drug delivery system based on VNPs offer diverse advantages over synthetic nanoparticles, including biocompatibility, biodegradability, water solubility, and high uptake capability. Here we summarize the recent progress of VNPs especially as targeted anticancer vehicles from the encapsulation and surface modification mechanisms, involved viruses and VNPs, to their application potentials.
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