4.7 Review

Anodic electro-fermentation: Empowering anaerobic production processes via anodic respiration

期刊

BIOTECHNOLOGY ADVANCES
卷 48, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2021.107728

关键词

Anodic electro-fermentation; Microbial electrochemical technology; Aerobic vs; anaerobic production; Unbalanced fermentation; Terminal electron acceptor; Redox balance; Energy conservation; Bacillus subtilis; Acetoin

资金

  1. Academy of Finland [316657, 319910]
  2. ECR Development Fellowship from The University of Queensland
  3. Academy of Finland (AKA) [316657, 319910, 316657, 319910] Funding Source: Academy of Finland (AKA)

向作者/读者索取更多资源

The translation mainly discusses the importance of redox balance and energy conservation of microorganisms in nature and industrial production, and the principle and advantages of achieving this balance through anodic electro-fermentation technology.
In nature as well as in industrial microbiology, all microorganisms need to achieve redox balance. Their redox state and energy conservation highly depend on the availability of a terminal electron acceptor, for example oxygen in aerobic production processes. Under anaerobic conditions in the absence of an electron acceptor, redox balance is achieved via the production of reduced carbon-compounds (fermentation). An alternative strategy to artificially stabilize microbial redox and energy state is the use of anodic electro-fermentation (AEF). This emerging biotechnology empowers respiration under anaerobic conditions using the anode of a bioelectrochemical system as an undepletable terminal electron acceptor. Electrochemical control of redox metabolism and energy conservation via AEF can steer the carbon metabolism towards a product of interest and avoid the need for continuous and cost-inefficient supply of oxygen as well as the production of mixed reduced byproducts, as is the case in aerobic production and fermentation processes, respectively. The great challenge for AEF is to establish efficient extracellular electron transfer (EET) from the microbe to the anode and link it to central carbon metabolism to enhance the synthesis of a target product. This article reviews the advantages and challenges of AEF, EET mechanisms, microbial energy gain, and discusses the rational choice of substrateproduct couple as well as the choice of microbial catalyst. Besides, it discusses the potential of the industrial model-organism Bacillus subtilis as a promising candidate for AEF, which has not been yet considered for such an application. This prospective review contributes to a better understanding of how industrial microbiology can benefit from AEF and analyses key-factors required to successfully implement AEF processes. Overall, this work aims to advance the young research field especially by critically revisiting the fundamental aspects of AEF.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据