期刊
BIOSENSORS & BIOELECTRONICS
卷 182, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2021.113150
关键词
Neuron; Optical imaging with plasmonic enhancements; Optical neurostimulation; Optical sensor; Plasmonics; Surface plasmon resonance
类别
资金
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health Welfare [HI17C1501]
- National Research Foundation of Korea (NRF) grant by the Government of South Korea (Ministry of Science and ICT) [2018R1A4A1025623, 2020R1A2C4002732]
- National Research Foundation of Korea [2020R1A2C4002732] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study explores three plasmonic modalities as tools to study neurons and their responses, demonstrating the potential of plasmonic sensing, imaging, and stimulation techniques to effectively study neurons and understand their specific molecular activities.
Studies to understand the structure, functions, and electrophysiological properties of neurons have been conducted at the frontmost end of neuroscience. Such studies have led to the active development of highperformance research tools for exploring the neurobiology at the cellular and molecular level. Following this trend, research and application of plasmonics, which is a technology employed in high-sensitivity optical biosensors and high-resolution imaging, is essential for studying neurons, as plasmonic nanoprobes can be used to stimulate specific areas of cells. In this study, three plasmonic modalities were explored as tools to study neurons and their responses: (1) plasmonic sensing of neuronal activities and neuron-related chemicals; (2) performanceimproved optical imaging of neurons using plasmonic enhancements; and (3) plasmonic neuromodulations. Through a detailed investigation of these plasmonic modalities and research subjects that can be combined with them, it was confirmed that plasmonic sensing, imaging, and stimulation techniques have the potential to be effectively employed for the study of neurons and understanding their specific molecular activities.
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