Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors

In an in-house screening, 1H-pyrrolo[2,3-b]pyridine scaffold was found to have high inhibition on TNIK. Several series of compounds were designed and synthesized, among which some compounds had potent TNIK inhibition with IC50 values lower than 1 nM. Some compounds showed concentration-dependent characteristics of IL-2 inhibition. These results provided new applications of TNIK inhibitors and new prospects of TNIK as a drug target.

Automated summary

In an in-house screening, it was discovered that the 1H-pyrrolo[2,3-b]pyridine scaffold has high inhibition on TNIK. Several designed compounds showed potent TNIK inhibition with IC50 values lower than 1 nM, and some exhibited concentration-dependent characteristics of IL-2 inhibition. These results suggest new applications and prospects for TNIK inhibitors as a drug target.