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S. Schreml et al.
BRITISH JOURNAL OF DERMATOLOGY (2010)
Hyperbaric Oxygen Therapy for Diabetic Foot Wounds Has hope hurdled hype?
Benjamin A. Lipsky et al.
DIABETES CARE (2010)
Hyperbaric Oxygen Therapy Facilitates Healing of Chronic Foot Ulcers in Patients With Diabetes
Magnus Londahl et al.
DIABETES CARE (2010)
Preconditioning protects against oxidative injury involving hypoxia-inducible factor-1 and vascular endothelial growth factor in cultured astrocytes
Percy W. Y. Chu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen
Emily Flashman et al.
FEBS JOURNAL (2010)
Hypoxia-inducible factor (HIF)-3a is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2
Annika Pasanen et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)
Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production
Yee Liu Chua et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves
Namiko Abe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
Hongxia Z. Imtiyaz et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study
Chang H. Lee et al.
LANCET (2010)
2-Oxoglutarate oxygenases are inhibited by a range of transition metals
Rok Sekirnik et al.
METALLOMICS (2010)
Scarless Fetal Wound Healing: A Basic Science Review
Barrett J. Larson et al.
PLASTIC AND RECONSTRUCTIVE SURGERY (2010)
The Relationship between Inflammation and Regeneration in the MRL Mouse Potential Relevance for Putative Human Regenerative (Scarless Wound Healing) Capacities?
Ellen Heber-Katz et al.
LONGEVITY, REGENERATION, AND OPTIMAL HEALTH: INTEGRATING EASTERN AND WESTEN PERSPECTIVES (2009)
Hypoxia Inducible Factor-2α Stabilization and Maxi-K+ Channel β1-Subunit Gene Repression by Hypoxia in Cardiac Myocytes Role in Preconditioning
Lucia Bautista et al.
CIRCULATION RESEARCH (2009)
Regeneration According to Spallanzani
Panagiotis A. Tsonis et al.
DEVELOPMENTAL DYNAMICS (2009)
SWI/SNF Regulates the Cellular Response to Hypoxia
Niall S. Kenneth et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways
Ambreena Siddiq et al.
JOURNAL OF NEUROSCIENCE (2009)
Prolyl Hydroxylase Inhibitors Increase Neoangiogenesis and Callus Formation following Femur Fracture in Mice
Xing Shen et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2009)
Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis
Helen J. Knowles et al.
JOURNAL OF PATHOLOGY (2009)
HIF-1 alpha Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms
Alvaro Marin-Hernandez et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)
Retained features of embryonic metabolism in the adult MRL mouse
Robert K. Naviaux et al.
MOLECULAR GENETICS AND METABOLISM (2009)
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
Philipp Niethammer et al.
NATURE (2009)
Non-hypoxic Stabilization of Hypoxia-Inducible Factor Alpha (HIF-α): Relevance in Neural Progenitor/Stem Cells
Javorina Milosevic et al.
NEUROTOXICITY RESEARCH (2009)
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
Sergio Rey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Wound healing essentials: Let there be oxygen
Chandan K. Sen
WOUND REPAIR AND REGENERATION (2009)
Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse
Benjamin D. Ward et al.
ARTHRITIS AND RHEUMATISM (2008)
Mammalian regeneration and regenerative medicine
Ken Muneoka et al.
BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS (2008)
Transplantation of human neural stem cells protect against ischemia in a preventive mode via hypoxia-inducible factor-1α stabilization in the host brain
Kon Chu et al.
BRAIN RESEARCH (2008)
Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
Massimiliano Gnecchi et al.
CIRCULATION RESEARCH (2008)
Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds
Gayle M. Gordillo et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2008)
The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function
Gunbjorg Svineng et al.
CONNECTIVE TISSUE RESEARCH (2008)
Cost-effectiveness and budget impact of adjunctive hyperbaric oxygen therapy for diabetic foot ulcers
Anderson W. Chuck et al.
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE (2008)
Effect of Hyperbaric Oxygen Therapy on Healing of Diabetic Foot Ulcers
Arife Polat Duzgun et al.
JOURNAL OF FOOT & ANKLE SURGERY (2008)
Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes
Lynda A. Szczech et al.
KIDNEY INTERNATIONAL (2008)
Wound repair and regeneration
Geoffrey C. Gurtner et al.
NATURE (2008)
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
E. B. Rankin et al.
ONCOGENE (2008)
Evidence for articular cartilage regeneration in MRL/MpJ mice
J. Fitzgerald et al.
OSTEOARTHRITIS AND CARTILAGE (2008)
Transcriptional responses to intermittent hypoxia
Jayasri Nanduri et al.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2008)
Foreign body reaction to biomaterials
James M. Anderson et al.
SEMINARS IN IMMUNOLOGY (2008)
The use of hyperbaric oxygen therapy to treat chronic wounds: A review
Jennifer A. Thackham et al.
WOUND REPAIR AND REGENERATION (2008)
Initiation of limb regeneration: The critical steps for regenerative capacity
Hitoshi Yokoyama
DEVELOPMENT GROWTH & DIFFERENTIATION (2008)
Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1α stabilization during ischemia
Eric I. Chang et al.
CIRCULATION (2007)
Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia
Marta Bosch-Marce et al.
CIRCULATION RESEARCH (2007)
The N-terminal Transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1α and HIF-2α
Cheng-Jun Hu et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Persistent ischemia impairs myofibroblast development in wound granulation tissue: A new model of delayed wound healing
Navid Alizadeh et al.
WOUND REPAIR AND REGENERATION (2007)
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
Yoon-Young Jang et al.
BLOOD (2007)
Deer antler regeneration: Cells, concepts, and controversies
Uwe Kierdorf et al.
JOURNAL OF MORPHOLOGY (2007)
Hypoxia-inducible factors and cancer
M. J. Calzada et al.
CLINICAL & TRANSLATIONAL ONCOLOGY (2007)
Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure -: Results of the TOPCARE-CHD registry
Birgit Assmus et al.
CIRCULATION RESEARCH (2007)
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
Erinn B. Rankin et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Digit tip regrowth and differential gene expression in MRL/Mpj, DBA/2, and C57BL/6 mice
Robert B. Chadwick et al.
WOUND REPAIR AND REGENERATION (2007)
Chronic intermittent but not constant hypoxia decreases NAA/Cr ratios in neonatal mouse hippocampus and thalamus
Robert M. Douglas et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)
Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep
Barry W. Row et al.
BEHAVIOURAL BRAIN RESEARCH (2007)
Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: Novel pathways and targets for anticancer therapeutics
Rachel E. Airley et al.
CHEMOTHERAPY (2007)
Correction of anemia with epoetin alfa in chronic kidney disease
Ajay K. Singh et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Hyperoxic and hyperbaric-induced cardioprotection: Role of nitric oxide synthase 3
Bernadette P. Cabigas et al.
CARDIOVASCULAR RESEARCH (2006)
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes
Juan C. Chavez et al.
JOURNAL OF NEUROSCIENCE (2006)
Transforming growth factor β1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression
Stephanie McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Synergistic effects of CoCl2 and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells
Emilie Pacary et al.
JOURNAL OF CELL SCIENCE (2006)
Regulatory roles for mitochondria in the peri-implantation mouse blastocyst:: possible origins and developmental significance of differential ΔΨm
Jonathan Van Blerkom et al.
REPRODUCTION (2006)
Extracellular matrix deposition by fibroblasts is necessary to promote capillary-like tube formation in vitro
F Berthod et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1α) and HIF-2α in stem cells
CJ Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Mitochondria: Oxygen sinks rather than sensors?
RH Wenger
MEDICAL HYPOTHESES (2006)
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
K Rezwan et al.
BIOMATERIALS (2006)
Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues
EJ Soilleux et al.
HISTOPATHOLOGY (2005)
Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature
M Ueno et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)
Sleep-disordered breathing and cerebrovascular disease: A mechanistic approach
L Lavie
NEUROLOGIC CLINICS (2005)
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
MV Gustafsson et al.
DEVELOPMENTAL CELL (2005)
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
K Doege et al.
BLOOD (2005)
Oxidative stress in chronic venous leg ulcers
M Wlaschek et al.
WOUND REPAIR AND REGENERATION (2005)
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
KD Mansfield et al.
CELL METABOLISM (2005)
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
RD Guzy et al.
CELL METABOLISM (2005)
Human HIF-3 alpha 4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma
MA Maynard et al.
FASEB JOURNAL (2005)
The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids
B Banerji et al.
CHEMICAL COMMUNICATIONS (2005)
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1α and HIF-2α expression in lung epithelial cells -: Implication of natural antisense HIF-1α
T Uchida et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Crosstalk of hypoxia-mediated signaling pathways in upregulating plasminogen activator inhibitor-1 expression in keloid fibroblasts
QZ Zhang et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2004)
Increased vascular endothelial growth factor may account for elevated level of plasminogen activator inhibitor-1 via activating ERK1/2 in keloid fibroblasts
YD Wu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
RJ Appelhoff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
DJ Ceradini et al.
NATURE MEDICINE (2004)
BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia
TL Baker-Herman et al.
NATURE NEUROSCIENCE (2004)
Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene
F Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction -: Final one-year results of the TOPCARE-AMI trial
V Schächinger et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)
Impact of aging on gene expression in a rat model of ischemic cutaneous wound healing
JE Mogford et al.
JOURNAL OF SURGICAL RESEARCH (2004)
HIF-1α induces cell cycle arrest by functionally counteracting Myc
M Koshiji et al.
EMBO JOURNAL (2004)
Oxygen sensing by HIF hydroxylases
CJ Schofield et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Redistribution of intracellular oxygen in hypoxia by nitric oxide:: Effect on HIF1α
T Hagen et al.
SCIENCE (2003)
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
CJ Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Revisiting the essential role of oxygen in wound healing
GM Gordillo et al.
AMERICAN JOURNAL OF SURGERY (2003)
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
E Berra et al.
EMBO JOURNAL (2003)
Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers -: A prospective randomized study
L Kessler et al.
DIABETES CARE (2003)
Hypoxia is a major stimulator of osteoclast formation and bone resorption
TR Arnett et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2003)
The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial
A Abidia et al.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY (2003)
Cobalt inhibits the interaction between hypoxia-inducible factor-α and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-α
Y Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 uhiquitin ligase complex
MA Maynard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor κB activation
YJ Jung et al.
BIOCHEMICAL JOURNAL (2003)
Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization
J Yamaguchi et al.
CIRCULATION (2003)
Extending the table of stages of normal development of the axolotl: Limb development
HLD Nye et al.
DEVELOPMENTAL DYNAMICS (2003)
Matrix metalloproteinase activity correlates with blastema formation in the regenerating MRL mouse ear hole model
D Gourevitch et al.
DEVELOPMENTAL DYNAMICS (2003)
Mechanisms of hypoxic regulation of plasminogen activator inhibitor-1 gene expression in keloid fibroblasts
QZ Zhang et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)
Hypertrophic scars and keloids - Etiology and management
TS Alster et al.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2003)
Widespread, hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs
MS Wiesener et al.
FASEB JOURNAL (2002)
Increased migration of murine keratinocytes under hypoxia is mediated by induction of urokinase plasminogen activator
RJ Daniel et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2002)
Esophageal ulceration triggers expression of hypoxia-inducible factor-1α and activates vascular endothelial growth factor gene -: Implications for angiogenesis and ulcer healing
D Baatar et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells
SK Lin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway
JS Isaacs et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Loss of HIF-2 and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
V Compernolle et al.
NATURE MEDICINE (2002)
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
D Lando et al.
GENES & DEVELOPMENT (2002)
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
SJ Freedman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Mammalian EGLN genes have distinct patterns of mRNA expression and regulation
ME Lieb et al.
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE (2002)
Heart regeneration in adult MRL mice
JM Leferovich et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Differential activation of migration by hypoxia in keratinocytes isolated from donors of increasing age: Implication for chronic wounds in the elderly
YP Xia et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
ME Cockman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
KL Talks et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
M Ohh et al.
NATURE CELL BIOLOGY (2000)
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