4.1 Article

Intracellular host cell membrane remodelling induced by SARS-CoV-2 infection in vitro

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Morphology and morphogenesis of SARS-CoV-2 in Vero-E6 cells

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Summary: This study aimed to investigate the ultrastructural biology of SARS-CoV-2 in Vero-E6 cells. Through transmission electron microscopy and real-time reverse transcription polymerase chain reaction (RT-PCR), the infection of Vero-E6 cells with SARS-CoV-2 samples isolated from Brazilian patients was documented. The susceptibility of Vero-E6 cells to SARS-CoV-2 infection and the viral pathway inside the cells were demonstrated by ultrastructural analysis, showing cytopathic effects and viral entry mechanisms.

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