期刊
BIOESSAYS
卷 43, 期 5, 页码 -出版社
WILEY
DOI: 10.1002/bies.202000273
关键词
ageing; differentiation; epigenetics; mesenchymal stem cells; metabolism
资金
- Onassis Foundation [FZP047-1/2019-2020]
- MaxPlanck Society
This study highlights the coordinated control of bone-marrow mesenchymal stem cell (BM-MSC) proliferation and lineage commitment by metabolism and epigenetics, as well as the important role of metabolism in driving stem cell fate decisions through alterations of chromatin landscape. Age-associated changes in metabolism and the epigenome disturb the balance between stem cell proliferation and differentiation, leading to stem cell depletion, fat accumulation, and bone-quality related diseases. Understanding the dynamics of the metabolism-chromatin interplay is crucial for maintaining the stem cell pool and delaying aging.
Bone-marrow mesenchymal stem cell (BM-MSC) proliferation and lineage commitment are under the coordinated control of metabolism and epigenetics; the MSC niche contains low oxygen, which is an important determinant of the cellular metabolic state. In turn, metabolism drives stem cell fate decisions via alterations of the chromatin landscape. Due to the fundamental role of BM-MSCs in the development of adipose tissue, bones and cartilage, age-associated changes in metabolism and the epigenome perturb the balance between stem cell proliferation and differentiation leading to stem cell depletion, fat accumulation and bone-quality related diseases. Therefore, understanding the dynamics of the metabolism-chromatin interplay is crucial for maintaining the stem cell pool and delaying the development and progression of ageing. This review summarizes the current knowledge on the role of metabolism in stem cell identity and highlights the impact of the metabolic inputs on the epigenome, with regards to stemness and pluripotency.
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