New drug targets for hypertension: A literature review

Hypertension is one of the most prevalent cardiovascular diseases worldwide. However, in the population of resistant hypertension, blood pressure is difficult to control effectively. Moreover, antihypertensive drugs may have adverse effect currently. Hence, new therapeutic targets and treatments are needed to uncovered and exploited to control hypertension and its comorbidities. In the past, classical drug targets, such as the aldostemne receptor, aldostemne synthase, and ACE2/angiotensin 1-7/Mas receptor axis, have been investigated. Recently, vaccines and drugs targeting the gastrointestinal micmbiome, which represent drug classes, have also been investigated for the management of blood pressure. In this review, we summarized current knowledge on classical and new drug targets and discussed the potential utility of new drugs in the treatment of hypertension.

Automated summary

Hypertension is a common cardiovascular disease globally, with resistant hypertension being difficult to control effectively. Current antihypertensive drugs may have adverse effects, highlighting the need for new therapeutic targets and treatments to manage hypertension and its comorbidities.