期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1866, 期 2, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbalip.2020.158857
关键词
Lipidomics; Metabolomics; Systems biology; Genome-scale metabolic modeling; Disease biomarkers
资金
- Novo Nordisk Foundation [NNF19OC0057418]
- Academy of Finland [323171]
- Swedish Research Council [2016-05176, 201802629]
- Swedish Research Council [2016-05176] Funding Source: Swedish Research Council
- Academy of Finland (AKA) [323171, 323171] Funding Source: Academy of Finland (AKA)
Lipids play important roles in biology, such as energy storage and cell membrane structure. Lipid metabolism is tightly regulated, and disturbances in lipid-related pathways are involved in the pathogenesis of common diseases. Advances in lipidomics provide new methods for lipid research.
Lipids have many important biological roles, such as energy storage sources, structural components of plasma membranes and as intermediates in metabolic and signaling pathways. Lipid metabolism is under tight homeostatic control, exhibiting spatial and dynamic complexity at multiple levels. Consequently, lipid-related disturbances play important roles in the pathogenesis of most of the common diseases. Lipidomics, defined as the study of lipidomes in biological systems, has emerged as a rapidly-growing field. Due to the chemical and functional diversity of lipids, the application of a systems biology approach is essential if one is to address lipid functionality at different physiological levels. In parallel with analytical advances to measure lipids in biological matrices, the field of computational lipidomics has been rapidly advancing, enabling modeling of lipidomes in their pathway, spatial and dynamic contexts. This review focuses on recent progress in systems biology approaches to study lipids in health and disease, with specific emphasis on methodological advances and biomedical applications.
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