期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1862, 期 2, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbabio.2020.148338
关键词
Hydrogen sulfide; Persulfides and polysulfides; Signaling molecules; Protein persulfidation; Cancer
资金
- Ministero dell'Istruzione, dell'Universita e della Ricerca of Italy [PRIN 20158EB2CM_003]
- iNOVA4Health Research Unit [LISBOA-01-0145-FEDER-007344]
- FCT/Ministerio da Ciencia e do Ensino Superior, through national funds
- FEDER under the PT2020 Partnership Agreement
Sulfane sulfur species, which include various biologically relevant compounds and proteins, play a significant role in cancer biology by modulating cell bioenergetics and contributing to metabolic reprogramming. They achieve this by binding to target proteins or sulfidating specific cysteine residues, thereby regulating cellular functions and exhibiting anti-tumoral properties.
Sulfane sulfur species comprise a variety of biologically relevant hydrogen sulfide (H2S)-derived species, including per- and poly-sulfidated low molecular weight compounds and proteins. A growing body of evidence suggests that H2S, currently recognized as a key signaling molecule in human physiology and pathophysiology, plays an important role in cancer biology by modulating cell bioenergetics and contributing to metabolic reprogramming. This is accomplished through functional modulation of target proteins via H2S binding to heme iron centers or H2S-mediated reversible per- or poly-sulfidation of specific cysteine residues. Since sulfane sulfur species are increasingly viewed not only as a major source of H2S but also as key mediators of some of the biological effects commonly attributed to H2S, the multifaceted role of these species in cancer biology is reviewed here with reference to H2S, focusing on their metabolism, signaling function, impact on cell bioenergetics and anti-tumoral properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据