期刊
BIOCHEMICAL JOURNAL
卷 478, 期 3, 页码 597-617出版社
PORTLAND PRESS LTD
DOI: 10.1042/BCJ20200167
关键词
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资金
- Argentinean National Agency for Promotion of Science and Technology [PICT 2014-3687, 2017-0494, 2018-2602 PICT]
- Fundacion Sales
- Fundacion Bunge and Born
- Fundacion Baron
- Richard Lounsbery Foundation
The metastatic cascade promotes tumor progression by regulating interactions between tumor cells and other cells. Metastatic cells must undergo four attributes including motility, modulation of microenvironment, cell plasticity and colonization, which directly impact the outcome of metastasis.
A sequence of interconnected events known as the metastatic cascade promotes tumor progression by regulating cellular and molecular interactions between tumor, stromal, endothelial, and immune cells both locally and systemically. Recently, a new concept has emerged to better describe this process by defining four attributes that metastatic cells should undergo. Every individual hallmark represents a unique trait of a metastatic cell that impacts directly in the outcome of the metastasis process. These critical features, known as the hallmarks of metastasis, include motility and invasion, modulation of the microenvironment, cell plasticity and colonization. They are hierarchically regulated at different levels by several factors, including galectins, a highly conserved family of beta-galactoside-binding proteins abundantly expressed in tumor microenvironments and sites of metastasis. In this review, we discuss the role of galectins in modulating each hallmark of metastasis, highlighting novel therapeutic opportunities for treating the metastatic disease.
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